Yeah I'm leaning more towards the sativa hybrids after reading some journals. You're right though, I think some sativas can be a bit too much for people who don't normally smoke it.
Geez buddy, that's no good about your Mum, I hope it doesn't set her back. My godmother is constantly sick with pneumonia and has lost a lot of her memory, some days she has no idea who I am, it totally destroys me and I can see it really upsets her too. At least your Mum has you mate and I'm sure you'll find something to relieve her symptoms. Thanks for your kind wishes too mate!
Thanks for the info mate, I'll look into the diesels and jillybean. I hope you can find some relief too!!
Cool, thanks mate, that's good to know! Do you mind me asking what it is about the high CBD that your Mum doesn't like? Cheers bud.
Also found an interesting journal through my uni, I'll upload the full article when I'm on my PC.
Purified Cannabidiol, the main non-psychotropic component of Cannabissativa, alone, counteracts neuronal apoptosis in experimental multiplesclerosis
By:
Giacoppo, S (Giacoppo, S.)
[ 1 ] ;
Rajan, TS(Rajan, T. Soundara)
[ 1 ] ;
Galuppo, M (Galuppo, M.)
[1 ] ;
Pollastro, F (Pollastro, F.)
[ 2 ] ;
Grassi, G (Grassi, G.)
[ 3 ] ;
Bramanti, P (Bramanti, P.)
[ 1 ] ;
Mazzon, E(Mazzon, E.)
[ 1 ]
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
Volume: 19
Issue: 24
Pages: 4906-4919
Published: DEC 2015
View Journal Information
Abstract
OBJECTIVE: Multiple Sclerosis (MS) is a global concern disease leading to a progressive, chronic and demyelinating condition, affecting the central nervous system (CNS). The pathology has an inflammatory/autoimmune origin; nevertheless, neuronal cell death mechanisms are not to be underestimated. The present study was designed to test the effects of intraperitoneal administration of cannabidiol (CBD), the main non-psychotropic cannabinoid of Cannabis sativa (CS), in an experimental model of MS. The aim is to evaluate the capability of CBD administration to thwart the cascade of mediators involved in MS-induced apoptosis.
MATERIALS AND METHODS: Experimental Autoimmune Encephalomyelitis (EAE) was induced by immunization with myelin oligodendroglial glycoprotein (MOG)(35-55) peptide in mice. After immunization, mice were observed daily for signs of EAE and weight loss. Disease signs were evaluated using a standardized scoring system.
RESULTS: Immunohistochemical and Western blot assessments of key apoptotic markers reveal that CBD treatment is able to avoid Fas pathway activation, phospho-ERK p42/44 and cleaved caspase-3 triggering as well as alterations in mitochondrial permeability due to Bax/Bcl-2 unbalance. Moreover, CBD interferes with p53-p21 axis activation. As results, the absence of tissue apobody formation in spinal cord tissues of EAE-mice treated with CBD was established. Most of therapeutic properties of CS are currently ascribed to the psychotropic effects of phenylterpenoid delta-9 tetrahydrocannabinol.
CONCLUSIONS: We have demonstrated that, alone, purified CBD possesses an anti-apoptotic power against the neurodegenerat ive processes underlying MS development. This represents an interesting new profile of CBD that could lead to its introduction in the clinical management of MS.
