Right now I'm Shooting up 6 quart bags of bulk with my LC and waiting for that to colonize. You guys think I'd use the whole six in a monotub? Since I can control the temp and humidity of the whole room would it be easier to have it set to 92 humidity and leave the top of the mono off?
Keep everything at least a foot off the floor. Most of your contams are down there.
Make sure you have decent airflow. Setup 4 inch ducts all over the place with holes in them for air distribution. Don't go crazy for high volume as if you were using it for cooling a green grow room, just you do NOT want pockets of stagnant air.
Get a couple of aircleaners. Ones with ionisers on them. Then get a couple more ionisers. You want to keep down the stray bacteria, and you do not want to start growing shit in your walls. This is a warm humid environment, and shit will be growing EVERYWHERE.
Make sure EVERYTHING is cleanable.
Cover every bit possible with plastic and tape. Tape BOTH sides of the plastic before staplegunning it (keeps it from splitting). You can use 6 mil plastic or tarps. Do your floor with tarp. Thin and cheap for walls, thick for the floor.
Waterproof outdoor tape combined with plastic combined with an electric staplegun. Buy many extra boxes of staples. Doublecheck your gun will actually penetrate your walls and how deep. I have 2 guns, 1 of which can drive 1/2inch staples into my floor, the other cannot. Exposed staples HURT.
Get a bunch of baker's racks. These are cheap open air metal shelving that have bars for each shelf. Both strong and easy to move and clean, and fully adjustable.
Get a bunch of wireties. Get a bunch of clip on lights.
Get a timer (damn, I'm easing into train/admin spotting here, gotta cut that shit out)
Ok, back to your question.
6qts in a single, sure. Depends on how much substrate you want to do vs how fast you want to fruit. More substrate == slower but will have more shrooms when done since they had more nutrition.
If I were you, I'd map out EXACTLY how many tubs you could be fruiting, assume 8 qts for each, and go buy enough rye grain and quart jars to fill them. In my case I can PC 8 quarts at a time, so a couple of days of cooking and I'd be done.