No, they should be fine. When i was doin the AG, i had to cut a male out so i just cut the stem at the lowest point possible, and covered up the grow hole. My females grew after that with no problem.
Well if you've used it before it with no problems it should be fine, i was just saying so that the plants dont get stunted. happened to me when i used some soil that didn't have and perlite in it.