You can do one plant on a 400w, but heat might be an issue depending on the size of the space your using and the ventilation. Seems a bit over kill for the cost though, because I doubt it will increase yields enough to make up for the increased cost of electricity. I'm personally running 6 under a 400w, and would be fine to go up to 8-9 if I planned to used a sog or scrog method where you keep the plants short. As it is I'm planning to grow them to around 6 ft, and will end up needing to get a supplementary light or two by the time I'm a few weeks into flowering.