Big plants or small plants? LST, or SOG or ScroG or none of them? Is the goal to grow as many plants as possible, or is the goal to grow as much bud in one harvest as possible, or is the goal to grow as many ounces per month as possible? For as many plants as possible, use SOG from clones, could probably do about 144 small popsicle-style plants. For as much bud as possible in one harvest, grow 16 plants and veg them for three months before flowering. For as much bud/month as possible, mmm, I'd say 16-24 plants and a ScroG.
All depends on what the goal is.