I keep it around 40-60............too low and it helps out the bugs, too high and it helps out the molds, plus slows transpiration hence growth......so try for a happy medium. Our climate is very dry, so I use a swamp cooler in the summer and just take what I have in the winter when temps are lower.....with all the rezs, wet cubes and flood/drain it'll hold around 40% in the winter and 50% in the summer...compared with 30% or less outside.......
In an extreme case of mite infestation, I drive it up to 75% for a few days and lower the temps....but more than a few days invites rot and I end up having to bleach the walls after the treatment. It helps slow down the reproductive cycle until I get them back under control.....
I think 22% is a little too low, but not in and of itself unhealthy.........you can mist the area to help or add a humidifier.....