well depend how much u know and what kinda gear u got
i have never used anything cept coco, for the last 6 grows, it workd great with GH 3 part nutes (lucas formula 2 part) i had salt buildup problem though
i recomend ppl that want to do soiless to just use the hempy bucket method, if u wana use coco, mix it 50/50 with perlite
personaly i am planning on droppign coco ( costs to damn much) and im gana use 100% perlite