Synthetic Weed and Tolerance

I've been smoking some synthetic stuff that's ok lately while I haven't been smoking weed but I was thinking that this stuff still might be contributing to my cannabis tolerance because its a cannaboid. Any thoughts are appreciated.

Synthetic cannabinoids will increase your tolerance to natural ones as well. It's not a complete cross tolerance but it's definitely significant.

The synthetic cannabinoids like JWH-018, JWH-200, and CP-47,497 are complete receptor agonists, which means they will bind to cannabinoid receptors for life. Once triggered by these synthetic compounds, the receptor is for all intents and purposes dead. You have to wait for the receptor to recycle (the old one to be destroyed and a new one made) before the tolerance is overcome. THC, CBD and CBN are incomplete receptor agonists, which means they bind to the cannabinoid receptor and eventually release, opening the receptor up to be activated again. Tolerance with smoking pot is much shorter for this reason. There is nothing worse you can do for your tolerance than switching to synthetic "spice." With many receptors in the body there is a feedback mechanism to signal that more are required when needed, but this doesn't appear to be the case for cannabinoid receptors, at least CR1 and CR2. They regenerate at a steady rate regardless of how many are functional.

In addition, we don't fully understand the function of endocannabinoids (the ones your body naturally produces to interact with your cannabinoid receptors). These receptors don't just exist for you to get high off weed, they have a function in the body and are activated by cannabinoids that your own body produces to perform some function. Probably (most definitely) as neurotransmitters, although a lot of ongoing research is suggesting they play multiple roles in multiple systems, including blood pressure regulation, immune system recruitment at critical stages in tumor development (i.e. anti-cancer properties), and nerve cell signaling unrelated to nerve impulses (like chemotaxis, or signaling the environment around a nerve cell that there's something it needs, like a hunger signal. Cells have to eat, too). There are at least 2 cannabinoid receptors and possibly as many as 4 additional (with more candidates emerging all the time) distributed through many different tissues and systems in the body, so it makes sense that they would play multiple roles. When you smoke weed you're just borrowing your cannabinoid receptors from their normal function for a little while, THC is not their natural signaling molecule. So you're not only jacking up your tolerance levels, you're cutting off your cannabinoid receptors from performing their natural function as well, which could end up affecting multiple systems in the body.

Synthetic weed is a bad idea for a lot of different reasons, some probably more important than jacking up tolerance.

Cheers.

My tolerance was sky high just smoking weed and taking a tolerance break from that didn't do anything.

im kind of worried about that too. I've been smoking that synthetic stuff but it doesn't contain any jwh. I am on random drug tests for probation. I am smoking the synthetic stuff not as much as I did mj though. just until I get off this random crappy. the day I get off this random is the day I'm getting hammered. I couldn't even drink a beer on my birthday Wtf.

do you think I will be able to get high off mj after I've been casually smoking synthetic for about 2 months?

@Amazingsandlad That's not how full agonists bind. That's how irreversible ligands (which can be full agonists, partial agonists, or antagonists) bind. Compare the duration of morphine, a full mu-opioid agonist, with the duration of oxymorphazone, an irreversible full mu-opioid agonist. Morphine lasts 4-8 hours, while oxymorphazone lasts until the receptors are recycled (24+ hours).
The difference is that tolerance to a full agonist builds faster than tolerance to a partial agonist. Tolerance to a full agonist can be raised high enough that partial agonists become ineffective because they can't activate the receptor enough to cause the desired effect.
To use opioids as an example again (we know much more about them that cannabinoids) let's look at buprenorphine (the active ingredient in Suboxone and Subutex and a partial mu-opioid receptor agonist). In opioid naive individuals a dose of 1-2mg produces a typical opioid buzz. When someone who has a tolerance to opioids is given the same dose they won't get high. Depending on how high their tolerance is it might not be possible for them to get high from any dose before the buprenorphine starts antagonizing itself. So using synthetic full cannabinoid receptor agonists can raise your tolerance to a point where THC can't get you there.
So receptor ligands can be irreversible or reversible depending on how they bind. Reversible ligands bind by using weaker intermolecular forces like hydrogen binding or dipole dipole interactions (<20kcal/mol), while irreversible ligands form covalent bonds with the receptor (100+ kcal/mol). That's an enormous difference in energy barrier, one reaction will go fast at body temp, the other won't go at all.

Tried that synthetic stuff and , just the way it made me feel well nah I didn't like that at all . Theres no telling what prolonged usage could do to your body and mind either .

I was using spice Colorado chronic black diamond was my fav I was so hi I jus wanted to no
Wen was my next hit but I was deep like mj was doin that for 7 months n I was already having problems
I was smokin like 10 joints im not proud of it n I was getting chest pains n cudnt breath at times I decided to quit
or its gonna b the end of me so I stoped since but im on probation n not lookin bak but weed god I miss it but ill prolly get
the old brand of spice I used to smoke n get some hi grade bud n roll it up jus to c but spice constatly will couse problems if u smoke a ton!