even if you have 2 different strains, there will be different phenotypes so yes there can be a difference. if you have the space to grow them then do the crosses both ways.
this is only what i have heard and not from personal experience
females more strongly influence
type of taste /smell
flower structure and yeild
potency and resin production
males strongly influence
amount of taste / smell
flowering length and finish
branch and fiber strength/production