It just depends on the CFM and size pipe u are using..........I vent a small box with one 4", similar setup. You wont want to put them all in a big line, use a Tee, and put your fan @ the end of the line, or beginning. I had better results with the end of line with the carbon filter attached. Hopefully, your cool tube has its own passive intake, that would be better as well. The less ducting, the more flow. And that cheap ducting is junk, and slows air flow. You want the strong flex type, cuts out sound too. Good luck!!