I would defoliate now to open up for some light to hit all the bud sites and then on day 21 of flower. Thats how i do it! Works out good for me. Those are some bushes. Lol wow but they look really good great job!
If you're growing them outdoors leave the leaves alone. Inside just remove ones that aren't getting any light at all around the base then maybe take a bunch off the last week or two of flower to let shaded buds ripen in the light better. Buds grow fine in the shade but need light to finish up faster.