I'll say this now that i have the negative stuff out of the way.
Imo you'll want to divide that space into at least five compartments.
Two will be flower rooms on alternating 12/12.
One will be the "veg nursery" under 18/6 or 20/4.
One will be clones and moms, where you produce the next platoon of clones for the growth areas.
And one would be "engineering", where you keep your supplies, your water purifier, chillers/heaters/big pumps, spare ballasts etc. and mix nutes and other plant chems. I would seriously think about compounding your own salt ferts. Get McCaskill's book on making hydro nutrient.
If you want to go true hydro, I would gravitate toward NFT in six-inch drain pipe. Modular, fairly easy to build and run, efficient for growing and nute use.
But i would also give drain-to-waste soilless in a coir-based medium (e.g. Sunshine Mix Advanced) a serious think. You'll be laboring a lot with individual pots, but this method shines when something isn't going right. You can remove and quarantine problem plants (herms, sickies, runts) very easily, and unlike NFT or undercurent, where your plant geometries are rigid and in groups, you can shift things around. Also this is drain to waste. You never worry about reusing nute or passing something from one plant to the next ... and if you make a nute mistake or want to change the strength or blend, you can do so at the speed of thought. It is a very responsive and flexible system with a low mechanical overhead per plant, and both i and a respected grow friend have had results such that this is now our "go to" overall approach regardless of scale.