I think its best to cut clones after the plant is 6 weeks old. But many people I know take them much earlier. I like to cut them about 4-5 inches tall, but I just took some that were only about 3 inches tall. It s all a matter of preference! I always leave at least two sets of leaves, but three would be better! Also I've heard clones taken from the bottom of the plant will root faster. Good luck!