Yeah I have been trying to balance some of these factors myself, recently set up a 4x8 in some of my veg space to hunt some genetics in and ran vpd around 1.0 through the first 5 weeks of flower, lights on temps and humidity were 81-82f and 70-73% rh. Was not sure what to expect as its been a long time since I flowered in anything other than a sealed room with co2, ac dehu etc, but really enjoying the test tent so far. Anyways around week 5 I started to get nervous about the humidity esp during the night cycle, where it would hit 75 and cause the fans to ramp up. I am using an aci 6" for intake and an 8 for exhaust. I have them set on speed 4 as the minimum and it moves quite a lot of air through the tent even then but when they ramp up its like a wind tunnel. I have 5 or so walmart clip fans and a 9" floor fan in there also since I was worried about the high humidity with it being in the veg room. Even with all this airflow I decided to move a small dehumidifier into the veg room and positioned the intake duct for the tent right at the outlet of the dehu and this dropped rh inside the tent down to the 65-68 range where I am a more comfortable, but still fairly high. Some of the phenos in there are crazy dense so I am still a little worried avout mold but I think the amount of airflow being pulled through the canopy really helps. Its coming down next week so I will know for sure then but so far I havent seen any signs of it. I also sprayed the plants with regalia on day 3 of flower and have been using it in a drench every 10 days to further protect against mold.
TLDR ran 70+% humidity through week 5 of flower- 1.0 target vpd, tons of airflow and tent packed full of dense colas, 8th week now no mold.