In a technical sense,,no and yes...You see, synthetics are formulated to be directly available to the plant, with out having to be "changed" by the bio's in the soil to be available to the plant (I left out the scientific wording for ease of understanding).
That being said. I have seen an effect to plants running synthetic's.....Fulvic's do supply to the synthetic grow those B vits and some natural PGR's that come from the Kelp/seaweeds that are mostly used as the source for them. The use of Kelp based fulvic's tend to preclude the need for things like Hesi Super Vit, Thrive Alive or any other Vitamin/PGR source supplement.
Fulvic's aid in the same way Humic's do, but because they are soluble in alkaline, acid and neutral environments they aid greatly in the uptake of N,P,K,Mg,S and a host of micronutrients. This is done because the Fulvic's are readily absorbed by the plants roots and "carry" the things listed above into the plant with ease....The use of synthetic nutrition does not "require" fulvic acids to do the job....Although many do include some in one way or another.
Danny is looking into this with both, in relation to synthetic use. I suspect that they do continue to aid in the uptake as "carriers" of these nutrients, because they so easily pick them up when in solution. The synthetics are already in solution (useable). So the Humic and fulvic acid take on these ready to go nutrients very easily and bring them into the plant faster.....Hence my need to reduce the nutrient feeding amounts when in use.....