We've found the potency more predictable and taste profiles better, just repacking and running again to glean anything we missed, though with a bi-flow CL system, it is seldom worthwhile.
As I see it, the control points for Medibles include purity, visual appeal, flavor, texture and potency.
Purity would be diminished by the presence of any residual solvent picked up, plus the ratio of targeted elements to non targeted elements extracted changes, when you take away most of the targeted elements in the first extraction.
Visual appeal may be difficult to maintain in some medibles where the ratios of fat or oils are increased to meet potency requirements.
The flavor of residual solvents and non targeted elements affect flavor.
Texture is also changed by the fat to other components ratio of the recipe.
Two issues on potency. The first is that the cannabinoids and terpenes don't extract in direct proportion to their levels in the plant, because of their different molecular weights and boiling points, so the second extraction will have a higher ration of the heavier molecular weights, and higher boiling points. In my experience those heavier elements are more sedative, with less head effects.
With most of the targeted elements removed, you have to reclaim large amounts of material to approach the same potency using oil or glycerin, because you can't condense them once they are saturated, to increase concentration. You are at best left with a saturated solvent.