It is safe but only the leaves, A little on the buds won’t hurt but they’re not your main focus. Top bottom of leaf and the surface of the soil. You can use a gallon of clean water with a teaspoon of dish soap Which is an organic way to control mites. It must be straight from Misting spray bottle. Like I said it’s OK if it hits your nugs just focus on the leaves top and bottom and the surface of the soil. If you have to end up going nuclear you can buy AzaMax. Which works really well.