One of the pharma bigs; I forget whom; Glaxo? … had a “standardized” cannabis extract in oral spray form. It was big news ~12 years ago. It died on the vine. Imo the gate for smaller operators is open.
Sativex, THC and CBD is still being used mainly in the UK tho still here in Canada too tho only for a couple of problems.
Sativex (delta-9-tetrahydrocannabinol [THC] and cannabidiol [CBD])
Removal of Notice of Compliance with Conditions indications for Sativex:
The Indications section of the Canadian product monograph for Sativex has been revised to
remove the following indications, which were authorized under the Notice of Compliance with Conditions (NOC/c) policy, as the confirmatory clinical studies for these NOC/c indications did not support the therapeutic advantage of Sativex for neuropathic and cancer pain:
Footnote *
- Adjunctive treatment for the symptomatic relief of neuropathic pain in adult patients with multiple sclerosis.
- Adjunctive analgesic treatment in adult patients with advanced cancer who experience moderate to severe pain during the highest tolerated dose of strong opioid therapy for persistent background pain.
The Adverse Reactions, Clinical Trials, and Patient Medication Information sections have also been updated in relation to these removed NOC/c indications.
Key messages for healthcare professionals:Footnote 1
Sativex is now only indicated as adjunctive treatment for symptomatic relief of spasticity in adult patients with multiple sclerosis who have not responded adequately to other therapies and who demonstrate meaningful improvement during an initial trial of therapy.
- Healthcare professionals are encouraged to consider alternative options for treatment of patients with neuropathic or cancer pain.
Inclusion of information concerning use in hepatic impairment and drug interactions for Sativex:
The Warnings and Precautions and Action and Clinical Pharmacology sections of the Canadian product monograph for Sativex have been revised to include additional recommendations regarding use in patients with moderate or severe hepatic impairment.
The Drug Interactions and Patient Medication Information sections of the Canadian product monograph for Sativex have been revised to include additional information regarding potential drug interactions, such as those involving metabolizing enzymes cytochrome P450 (CYP) and uridine diphosphate-glucuronosyltransferase (UGT).
Key messages for healthcare professionals:Footnote 1
- Administration to patients with moderate or severe hepatic impairment is not advised due to higher peak concentration and exposure to THC, CBD, and their metabolites.
- Healthcare professionals are encouraged to refer to the product monograph concerning specific drug interactions with Sativex.
Reference
Footnote 1
Sativex (delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD)) [product monograph]. Cambridge (United Kingdom): GW Pharma Ltd; 2019.
My dad passed from cancer in '86 and had been prescribed some THC pills that I believe were made from synthetic THC. It just knocked him out for about 4 hours and he'd be groggy for the rest of the day. Did not stimulate his appetite and I was making protein/fruit smoothies for him which is about all he could get down that would stay down. I tried one of those and it was the same as some synthetic THC we bought down on 4th ave in Vancouver where we went to score acid and all sorts of goodies. UBC was just down the road so a lot of stuff was coming out of there. Almost like 'shrooms with mild hallucinations and just totally zoned me out. It was cut with green Freshie which is similar to Kool-Aid powder. So much good acid in the 70s there too. Probably still. I used to get 1000 lots of blotter for $250 and sell it for $2 a hit, 3 for $5 and made lots of money. Would get so high just sitting there cutting up sheets of blotter under a black light so you could see the dots and try to keep them centred in the dose. Half a hit would have a new user talking to god or trying to fly off a roof so you wanted to be able to cut accurate doses with no black light. Doses were all over the place anyways with some dots being bright purple under the light and others much dimmer. All manually done so how high was the guy eh? lol
Anyway my BIL and me got him to try pot. Worked so much better. Cheered him right up and gave him severe muchies so he'd down a whole blender full of smoothie while we played crib for a few games. Then he'd go nap for a couple hours and wake up in a good mood and hungry again. Too bad we didn't know about RSO etc back then. Might have saved him or at least bought him a few more decent years. Still miss the ol' man.