Wow, I Can't Believe Its Not Marijuana
- Thread starter timeismoney1
- Start date
The Cryptkeeper
Well-Known Member
Mental91
Active Member
JWH compounds can kill you trust me I know the synth to it and know alot about synthetic drugs from THC to cocaine to smack and I can tell you that JWH IMMEDIATELY causes DNA and cells to mutate which means cancer also it is only half a thc high and more of a PCP high chemical wise anyway I had to pay a chemist for this synth because I couldn't understand how the hell to mix 1-nafindola and dry DMSO to get the reaction I needed BTW should I post the synths for cocaine and heroin it's up to you guys I have it right in front of me https://www.rollitup.org/hallucinatory-substances/414361-jwh-018-synth-here.html#post5408384
The Cryptkeeper
Well-Known Member
I can't believe a person like you is actually on a forum like this.
timeismoney1
New Member
Thanks for spamming my thread mental. Great job!
Mental91
Active Member
Whats that supposed to mean?
Mental91
Active Member
I'm not spamming I mad a total of 3 posts so far including this one
The Cryptkeeper
Well-Known Member
Whatever you want it to mean.
timeismoney1
New Member
I think it means gtfo
timeismoney1
New Member
What do you think.
Your post saying it can kill you blah blah you think we dont know that!? Let alone safe doesing. Then you go on about the synth which was completly unrelated. Then you post a link jack my thread
Your post saying it can kill you blah blah you think we dont know that!? Let alone safe doesing. Then you go on about the synth which was completly unrelated. Then you post a link jack my thread
Mental91
Active Member
I posted a link because in this thread was a argument about whether it can kill you or not and it can cause problems unlike THC so I posted it. I figured it would settle the argument and people could get the actual facts. Other people that aren't members may look into JWH and not know whether it can cause cancer or not with an argument like that. BTW it also causes aggression maybe that's what your jackass is feeling. O 1 more thing you will know when the cancer is developing because it will cause pain in the back of the head along with tachycardia and pleura pain. Have fun you will die painfully over the next 1-5 years guaranteed
timeismoney1
New Member
I posted a link because in this thread was a argument about whether it can kill you or not and it can cause problems unlike THC so I posted it would settle the argument and people could get the actual facts other people that aren't members may look into and not know whether it can cause cancer or not with an argument like that BTW it also causes aggreasion maybe that's what your jackass is feeling O 1 more thing you will know when the cancer is developing because it will cause in the back of the head along with tachycardia and chest muscle pain have fun you will die painfully over the next 1-5 years guaranteed
Im just going to assume your just trying to be a cool guy...
WvMade
Well-Known Member
Straight off google......
So what is it?
"Fake weed"
Synthetic marijuana, marketed as K2 or Spice, is an herbal substance sold as an incense or smoking material that remains legal in the United States. The products contain one or more synthetic compounds that behave similarly to the primary psychoactive constituent of marijuana, &Delta9-tetrahydrocannabinol or THC.
The compound most commonly found in these products is a chemical first synthesized by the well-known Clemson University organic chemist, Prof John W Huffman: the eponymous JWH-018. Another compound, found in Spice products sold in Germany, is an analog of CP-47,497, a cannabinoid developed by Pfizer over 20 years ago.
Known as (1-pentyl-3-(1-naphthoyl)indole), or the more proper IUPAC name of Naphthalen-1-yl-(1-pentylindol-3-yl)methanone, JWH-018 is one of over 100 indoles, pyrroles, and indenes synthesized by the Huffman laboratory to develop cannabimimetics, drugs that mimic the effect of cannabinoids such as THC. The primary goal of these studies was to create pharmacological probes to 1) determine the structure-activity relationships of these compounds and 2) tease out the physiological function of subtypes of receptors we have for cannabinoids: the CB1 and CB2 receptors.
What does it do?
Much of the biological assessment work of Dr. Huffman's compounds was carried out by the laboratory of Professor Billy R. Martin of the Medical College of Virginia. Dr. Martin, a native of North Carolina, was a giant in the field and sadly left us two summers ago at the all-too-young age of 65 (obituary).
According to this 2000 paper in Drug and Alcohol Dependence from the Huffman and Martin groups, JWH-018 binds to the psychotropic CB1 receptor with approximately 4 times the potency of the naturally-occurring THC. Unlike THC, which binds with almost equal affinity to CB1 and CB2 receptors, JWH-018 exhibits a 3-fold preference for CB1 receptors.
What does this mean? Well, the CB1 receptor is the primary means by which cannabinoids exert their psychotropic effects. The CB2 receptor, on the other hand, appears to be more involved in pain and inflammation and is therefore a very active area of research for new therapeutics.
So while JWH-018 has four-fold greater potency for CB1 receptors than THC in an isolated receptor binding study, how its effect compares to plain-old marijuana depends on other factors such as the relative amount in the product, how stable it is to combustion, how it's metabolized in the body, among others.
"We don't know much about this, but it's going to end up killing somebody"
I'm not going out on a limb to say that this statement of Missouri Rep. Ward Frantz might be a bit hysterical at this point but I could be wrong. Human toxicology studies have not been done and the indole moiety of the drug dose raise the possibility that it may cause serotonin syndrome, a potentially fatal but relatively rare disorder. Otherwise, this concern is far overblown when compared with other drug issues in America's heartland such as methamphetamine.
"Surprised it took this long"
It's worth reading the backstory on Professor Huffman in this UK Guardian/The Observer article:
And with the perspective of a 77-year-old organic chemist:
So what is it?
"Fake weed"
Synthetic marijuana, marketed as K2 or Spice, is an herbal substance sold as an incense or smoking material that remains legal in the United States. The products contain one or more synthetic compounds that behave similarly to the primary psychoactive constituent of marijuana, &Delta9-tetrahydrocannabinol or THC.
The compound most commonly found in these products is a chemical first synthesized by the well-known Clemson University organic chemist, Prof John W Huffman: the eponymous JWH-018. Another compound, found in Spice products sold in Germany, is an analog of CP-47,497, a cannabinoid developed by Pfizer over 20 years ago. Known as (1-pentyl-3-(1-naphthoyl)indole), or the more proper IUPAC name of Naphthalen-1-yl-(1-pentylindol-3-yl)methanone, JWH-018 is one of over 100 indoles, pyrroles, and indenes synthesized by the Huffman laboratory to develop cannabimimetics, drugs that mimic the effect of cannabinoids such as THC. The primary goal of these studies was to create pharmacological probes to 1) determine the structure-activity relationships of these compounds and 2) tease out the physiological function of subtypes of receptors we have for cannabinoids: the CB1 and CB2 receptors.
What does it do?
Much of the biological assessment work of Dr. Huffman's compounds was carried out by the laboratory of Professor Billy R. Martin of the Medical College of Virginia. Dr. Martin, a native of North Carolina, was a giant in the field and sadly left us two summers ago at the all-too-young age of 65 (obituary).
According to this 2000 paper in Drug and Alcohol Dependence from the Huffman and Martin groups, JWH-018 binds to the psychotropic CB1 receptor with approximately 4 times the potency of the naturally-occurring THC. Unlike THC, which binds with almost equal affinity to CB1 and CB2 receptors, JWH-018 exhibits a 3-fold preference for CB1 receptors.
What does this mean? Well, the CB1 receptor is the primary means by which cannabinoids exert their psychotropic effects. The CB2 receptor, on the other hand, appears to be more involved in pain and inflammation and is therefore a very active area of research for new therapeutics.
So while JWH-018 has four-fold greater potency for CB1 receptors than THC in an isolated receptor binding study, how its effect compares to plain-old marijuana depends on other factors such as the relative amount in the product, how stable it is to combustion, how it's metabolized in the body, among others.
"We don't know much about this, but it's going to end up killing somebody"
I'm not going out on a limb to say that this statement of Missouri Rep. Ward Frantz might be a bit hysterical at this point but I could be wrong. Human toxicology studies have not been done and the indole moiety of the drug dose raise the possibility that it may cause serotonin syndrome, a potentially fatal but relatively rare disorder. Otherwise, this concern is far overblown when compared with other drug issues in America's heartland such as methamphetamine.
"Surprised it took this long"
It's worth reading the backstory on Professor Huffman in this UK Guardian/The Observer article:
JWH-018 was "nothing special", Dr Huffman remembered, "but it was one of the more potent compounds we made, and it was quite easy to make from commercially available materials. Probably the reason it has now caught on." [...]
[...]"My biggest surprise was that this all hadn't happened sooner," he told me. "All it needed was somebody with a reasonable understanding of science to see the papers we had published and think, 'Aha!'"
[...]"My biggest surprise was that this all hadn't happened sooner," he told me. "All it needed was somebody with a reasonable understanding of science to see the papers we had published and think, 'Aha!'"
And with the perspective of a 77-year-old organic chemist:
"I've lived around the world a long time," said Dr Huffman. "I've come to the conclusion that if an enterprising person wants to find a new way to get high, they're going to do it."
JWH-018 is however already classified as illegal in several European and Scandinavian countries. So unless JWH-018 does something different from garden-variety marijuana, outlawing it in the US will just push folks back to God's own herb.
The Cryptkeeper
Well-Known Member
I replied because you're spreading misinformation, repeatedly. Fine I will post my last post on this subject. You can overdose on THC. You can overdose on THC by smoking both pure THC, and by smoking Marijuana. There are unwanted effects of THC, and Marijuana. THC can cause aggression. I don't know about aggreasion, but I know it can cause aggression. JWHs can factor in to cancer, just like smoking ANYTHING can. The very last part of your run-on sentence post is complete bullshit. Basically everything in your sentence with the link to syntheses, is bullshit. I'm done discussing this, you are very misinformed, and may god have mercy on your soul.I posted a link because in this thread was a argument about whether it can kill you or not and it can cause problems unlike THC so I posted it would settle the argument and people could get the actual facts other people that aren't members may look into and not know whether it can cause cancer or not with an argument like that BTW it also causes aggreasion maybe that's what your jackass is feeling O 1 more thing you will know when the cancer is developing because it will cause in the back of the head along with tachycardia and chest muscle pain have fun you will die painfully over the next 1-5 years guaranteed
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