Anti-Coagulant Agent in Marijuana? Pics

[Lysemith, Lowkey]

I just smoked a week cured tester nug of my blueberry and I happened to scratch a small scab on my ankle/calf and it bled like hell! From experience I have been a quick clotter, having had several deep lacerations and whatnot over the years. Anyway, didn't know where to post, thought this was as good as any. I have considered diet and medication.

 

[dadio161]

are you saying you put marijuana on your leg ?
Not sure what you did to say that marijuana helped you stop bleeding.

 

[Lysemith, Lowkey]

No. Please try to read and understand the post: I medicated/smoked some of my cured medicine, then accidently scratched open a scab. I did not put marijuana on my leg.
Anti-coagulants act to keep the blood from oxidizing/clotting, having the exact reverse effect of what you mentioned:

that marijuana helped you stop bleeding.

Based on previous experience, I do not bleed that much, the only significant recent change being the medication.

 

[potpimp]

You're suggesting that cannabis has a compound in it like heparin. Birch bark (aspirin) does that and it would not be a surprise if cannabis did - not that that is a bad thing. Blood clots due to the interaction of two chemicals in the blood called fibrin and fibrinogen. They are long-chain proteins that bridge a wound like a spiders web. When the red blood cells, white blood cells and platelets are too big to go through the "web", the wound is clotted.

 

[dadio161]

I don't know if you can blame marijuana for your bleeding.
It could have been because of that Quarter Pounder you had for lunch.
Sue McDonalds !!

 

[Lysemith, Lowkey]

You're suggesting that cannabis has a compound in it like heparin. Birch bark (aspirin) does that and it would not be a surprise if cannabis did - not that that is a bad thing. Blood clots due to the interaction of two chemicals in the blood called fibrin and fibrinogen. They are long-chain proteins that bridge a wound like a spiders web. When the red blood cells, white blood cells and platelets are too big to go through the "web", the wound is clotted.

Thank you very much, I know there is quite a lot more to the mechanisms behind blood clotting, that was quite informative. There are many many examples of anti-coagulant enzymes and chemicals in nature, present in snails to bats to komodo dragons, but has anyone identified any chemicals that could be responsible for this action in cannabis?

 

[potpimp]

Oh yes, absolutely! Apparently there are several studies that confirm your eagle-eyed suspicion.
http://www.sciencedirect.com/science/article/pii/S0944711306000407

 

[ylem]

there are waaay too many factors involved in clotting to suggest cannabis had an effect on the scratch on your ankle. given the range and efficacy of the medicinal effects of cannabis, i wouldn't be surprised if a cannabinoid was found to have some kind of clotting properties. however, i do know for a fact that beta-caryophyllene has shown to possess significant anti-inflammatory properties.

 

[potpimp]

there are waaay too many factors involved in clotting to suggest cannabis had an effect on the scratch on your ankle. given the range and efficacy of the medicinal effects of cannabis, i wouldn't be surprised if a cannabinoid was found to have some kind of clotting properties. however, i do know for a fact that beta-caryophyllene has shown to possess significant anti-inflammatory properties.

My college major was medical lab technology and chemistry so I know by my formal education that clotting is a very simple mechanism. While there are any number of things that can directly effect clotting / inhibition, the fact remains that there are clinical trials that have been done and have found cannabis to be an anti-coagulant. This is not ambiguous and it's not to say that it's a bad thing that it is an anti-coagulant. The only people that should be concerned are hemopheliacs. On the whole, an anti-coagulant is better than a coagulant. It's better to have your blood a little to thin than too thick.

 

[silasraven]

I just smoked a week cured tester nug of my blueberry and I happened to scratch a small scab on my ankle/calf and it bled like hell! From experience I have been a quick clotter, having had several deep lacerations and whatnot over the years. Anyway, didn't know where to post, thought this was as good as any. I have considered diet and medication.

View attachment 1827154View attachment 1827155

sorry, but from me, i practice an old out dated methode called blood letting when my chemicals in my brain go fucked, i was stoned last time i did this and i swear the shit would bleed worth a damn

 

[Sarenna]

My college major was medical lab technology and chemistry so I know by my formal education that clotting is a very simple mechanism. While there are any number of things that can directly effect clotting / inhibition, the fact remains that there are clinical trials that have been done and have found cannabis to be an anti-coagulant. This is not ambiguous and it's not to say that it's a bad thing that it is an anti-coagulant. The only people that should be concerned are hemopheliacs. On the whole, an anti-coagulant is better than a coagulant. It's better to have your blood a little to thin than too thick.

My own research (similar background) absolutely correlates with what you've said. I've seen NIH articles warning about interactions between pot and warfarin and/or coumadin (two common blood thinners). Also, there's some exciting research going on regarding the anticoagulant properties of THC and CBN: http://marijuana.researchtoday.net/archive/4/4/736.htm .

Excellent observation!

 

[ThE sAtIvA hIgH]

just smoke it n get high dude your thinking far to much here .

 

[Lysemith, Lowkey]

just smoke it n get high dude your thinking far to much here .

With all due respect, fuck you.
To the rest of you guys, thanks tons for the confirmations of my suspicions, along with believable backup and articles. Particularly the interactions between warfarin and cannabinoids.

And you both posted the same experiment and paper from different sites.

 

[Jogro]

Coagulation is a little bit more complicated than above.

There is fibrin-mediated coagulation that follows an enzymatic clotting cascade (inhibited by coumadin, for example).
There is also a separate platelet-mediated coagulation that is inhibited by aspirin.

Given how many literally millions of dollars have been spent and are still being spent by drug companies to come up with new anticoagulants, its a crying shame how difficult it is to do research on simple cannabis in the USA.

 

[aperson1]

So I emailed one of the researchers who took part of the rat study and asked asked her about another study that claimed cannabis may actually be a pro-coagulant. This is what she emailed back(For reference, the "first" study is about the rats. And the "second" study is about the cannabis being a pro-coagulant) :

"Yes there is contradictory information in the literature and there are numerous factors that can contribute the varied findings amongst researchers.

Both our paper and the paper you referring to was completed when there was less information about the components of cannabis at the time these studies were completed. We used an extract and some of the individual cannabinoids that we could purchase at the time. Our paper focused on the anti-thrombotic activity of the cannabinoids. The second paper you refer to focused on THC and its anti-platelet activity. There are two different mechanisms at play in these various tests and when considering the data from both papers they are not contradicting each other as they investigate two different aspects of coagulation. We focused on the thrombin –induced clot formation and the ability of the cannabinoids to inhibit thrombin. The second paper focused on the ability of THC to activate platelet aggregation. and therefore two different aspects of coagulation. These two papers contribute in different ways to the understanding the effects of the cannabinoids on the coagulation system.

Since then it has become well established that other cannabinoids other than THC contribute to both an antagonist and agonist effects noted. As we used an extract for our rat model this could have contributed to the effects that we observed."

So it's not black and white. And you can't definitively say that THC is an anticoagulant; it could be a coagulant.