Yes! I went all out on my setup and seeds with no prior knowledge of what I was doing.
I am running some cream caramel autos in an aeroflo36 unit. I have made a few mistakes here and there, like not supplementing cal/mag (especially with using 900W LED!!!), too much nutes, air handler went out, and my hanna 98129 has failed me twice so far, requiring replacements both times and being left without a way to measure ec/ppm/ph/water temp.
It's def not how I planned everything out but now I've learned from it. It has cost me an additional 3 weeks time needed before chopping and def some bud weight, but I am happy to pay that price for the experience that I have acquired and will be able to apply to my next grow.
Sorry to rant, I'm blazed. Anyway, your question. There is no problem running autos in hydro that I myself, nor anyone that I know have encountered yet. Not sure what kind of setup you will be growing in, but my only issue is the spacing of plants with the aeroflo36 unit that im familiar with. If different phenos show up and grow at different rates, they get left behind by the others that tower over them, essentially blocking out light for growth, leaving you lost potential thats taking up space.
side note, I popped 36 cream caramel autos in rapid rooters and they were running in aero within 5 days in coco coir cups and hydrotron. Haven't lost any yet.
oh yea, and what was said regarding the nutes, be easy! I don't know your level of grow knowledge, but if you don't already, learn NPK and all of the micro nutes so that you know what they are and how they can work for and against your plant. Screw ups are less forgiving in hydro, I've learn first hand, and the whole time I was organizing and prepping my grow I was like "ah, this will be a piece of cake, add this, add that, stabilize, your good." Haha, was I wrong.
This is a generalization of what you can typically see from an autoflowering hydro grower in terms of his/her feeding dosages. Keyword - generalization. Different variables such as climate, strain, co2, water temp, personal preference, ect, can all affect the nutritional requirements of our ladies.
Week 2 - 200ppm
Week 3 - 350ppm
Week 4 - 500ppm
Week 5 - 650ppm
Week 6 - 700ppm
Week 7 - 800ppm
Week 8 - FLUSH
Again, sorry that my grammatical structure is lacking, causing my ideas to be thrown all over the place and questions to be answered indirectly, that OG got me stooooooned!