I've been pretty lucky when it comes to genetics. It seems like anything I've tried from the low key or little known breeders I have been satisfied with . Kannabia, Homegrown Fantaseeds, Ceres, Emerald Triangle, Magus (part of Serious Seeds now) have all been good to be.
It seems like anything I've grown from the big guys have ben mediocre at best. For example, I grew a single Sensi Super Skunk last year and don't get me wrong, it was a decent plant. No mold, finished early, and wasn't picky with the nutes. But it didn't get very big, had poor branching, and not much in terms of flavor or smell. There was nothing "skunky" about it. The year before I grew out a single Kannabia Special freebie. Now THAT was a skunky plant. Much better yield, finished around the same time, no mold, hardy, low maintenance, and just an all around better plant.
Reserva Privada is another big name breeder I didn't really care for. Last year I grew out a single Sour Kush (Headband) freebie. For starters, RP advertises it as mostly indica, but this plant looked mostly sativa to me. I had nothing but trouble with it. Very picky eater, the bugs loved it, grew weak and lanky, and didn't start flowering until the middle of August. To be fair, it was one of my plants that got ripped last year, so I didn't actually get to try any, but when it got ripped 1st week of October it still had a good 2-3 weeks of flowering left. The Emerald Triangle Lost Coast OG plant I had 6 feet away totaly blew it out of the water.
I realize only growing single seeds doesn't give much of a sample size to properly judge a strain. However, over the past few years I've grown out around 30 or 40 plants from seed. The overall trend seems to favor the obscure "no-name" breeders. I have pics of every strain I've grown if anyone is interested.