Well, if the heat can be controlled, the 400 will provide denser buds and a larger yield. However, it will also be overkill in that small space, as well as making much more heat than the 250. If you get a quality reflector, and have excellent reflection in the space itself, the 250 will be more than adequate. With all this in mind, a 250 in average hands provides for one daily smokers needs. A 400 can do more like three. Your spaces size limits realization of potential of a 400 w. You will get more, but you will get there with less efficiency.