You'll definitely want to invest in some booster fans with that huge network of ducting.
I cut my 2 car garage in half and put up 4-1000w lights and the result was spectacular, yet expensive!
Although now I have come to realize that 600w lights are the way to go.
I hope you can afford a elec. bill at about $2000.
I advise you don't use all those lights untill the final weeks of flower.
I would also run either a portable A/C or tie your CH/AC into your garage and run it when the lights are on.
Good luck bro, grow big!!!