How big is the room (the entire room not just the 100sqft of grow space)? You want to exchange all the air in the room at least every 5 minutes. More is better though. The fan is not just for air exchange. It's also for cooling the room. 1kW lights put out a lot of heat. So having a fan to exchange the air and separate fans to cool the lights is the best way to do it. Don't cool more than three lights with one fan.
I saw in your other thread that you're considering doing 6 lights. I think that might be biting off more than you can chew. You don't need to use the whole 100sqft. You can always expand later.
If I was setting up a grow in your space I would make separate veg and flower rooms to run a perpetual grow. I'd either get a tent or wall off a 5'x5' for moms and vegging. I'd use an area of about 2' x 3' lit by a 400W metal halide for the moms, a 2' x 2' area lit with some T5s for rooting clones and 2 3' x 3' areas for vegging each lit by a 600W metal halide, one of which would be dimmable so it could be set lower for the first few days to let the babies adjust from the T5s to the MHs. I'd take clones every two weeks a d give them two weeks to root. Then I'd move them under the dimmable light and dim it for a few days before turning it up to full power. They would stay under that light for a total of two weeks, then give them another two weeks under the other light (or make both lights dimmable and have the plants just stay under one light for four weeks total. Or do a nine week strain and change the cycle to every three weeks so you veg for 6 weeks total. It's a fair amount of work when you're running at full capacity. But harvesting less bud more frequently has a bunch of advantages. If you're growing commercially (which I'm assuming you are planning to do because 6kW of light worth of buds is a lot of weed to smoke by yourself) it's easier to get rid of a smaller amount more frequently than a large amount every few months. It also makes harvesting easier because you have less to trim at one time.
What medium are you planning on using?