forget 4x4s if you want to seriously do 5lbs per room every two weeks this is what you need..
each flowering room needs to have 1 4x8 ebb and flow table with a 100 gallon res running about 60 plants with 3 air cooled 1000w hps over the tops. that is 9000w just for flowering.
you will need to take about 70 clones every two weeks (two weeks prior to placing them in the flowering room)
for this i would suggest building 4 seperate ez cloners that you can veg the clones in for about 10 days after they root before transplanting them into your flowering room. i would personally use hydroton and square pots for this so that i could take them straight from the ebb and flo, into pots, acclemate the plants to the hps, and proceed to flower.
to take this many clones you will probably need at least 4-6 mothers that will need to be about 6 feet tall (you want to take absolutely no more than half of the plant at any cloning) and will want to have these mothers under at the minimum 1kw MH bulb.
plus in each room you are going to need proper cooling, proper ventalation and proper odor control.
you are talking about a big operation running at least 15000 watts with all the lights, timers, pumps, fans and ac. and that is if you dont live there as well.
this will take tens of thousands of dollars for the equip alone. months of startup time to get the mothers large enough for what you want to do, and a serious property and security to keep yourself safe.
now i dont mean to be a dick but judging about what you have been talking about and asking, my guess is you are not very familiar with growing.. take this advice, dont bite off more than you can chew. and dont even think about maintaining this all by yourself.. just to trip 5lbs every two weeks you will be putting in 20 hours a week just in trimming. i would def think long and hard about this, and do a lot more research
just my piece
FLo