I'm still not understanding. There are really only two refrigerants used in typical residential air conditioning applications: R22 and 410a. Of course, there is a slew of new R22 replacements, but you will not find a single new ac unit sold with anything except 410a in it. I've worked on thousands of ac units and have never come across a unit with anything other than R22 or 410a in it. I've converted some units to MO99, but that was at the request of a large customer.
I live/work in an area that gets up to 100F with 90+ humidity. If I'm changing out a dead 5 ton R22 unit, I put in a 5 ton 410a unit. While doing a manual J heat load, there is no input for R22 or 410a. This is because a 5 ton 410a unit produces the same 60,000 BTUs of cooling that a 5 ton R22 unit does. In the hundreds of change outs that I've done switching from R22 to 410a, I've never once had a customer complain about lack of cooling or high humidity. And trust me, my customers have no problem speaking up if they spend thousands of dollars and my work/equipment isn't satisfactory.
If anything, I've actually decreased the size of a new 410a unit while doing a change out. This isn't because a 5 ton 410a unit cools better, but rather too many hvac guys don't do proper manual J load calculations and over size equipment. This is where high humidity and mold problems come from. Have you ever been somewhere and had to turn the ac down to 70 or less to be comfortable? That is because the ac is over sized and not cycling long enough to remove the proper amount of humidity.