Victozap, if you have never tried that before I would recommend that you smoke something near even indica/sativa, or indica dominant. I have seen some people when mixing speed with sativas get pretty paranoid and such.
EDIT:
If you are healthy don't worry about it. I had been taking addies all night and smoking sativas like it was my job, my heart rate (after sitting down for over an hour) was 120bpm.
i been in and out of hospital,have had 3 operations and half me insides taken out,over the last 4 years,and been on loads of tablets which i still am,about 12 different ones i take,and during all this been smoking and taking stuff and my blood pressure and heart rate was ok,never once went high or nothing.nor did the smoking and taking what i was taking ever interefered,with any of my other tablets (prescribed ones )my 3 operations,any of the tests ive had,which ive had the full works,and done em all at least half a dozen times each,blood checked all the time,heart rate,blood presure,etc.but thats just my story,i supppose it will depend on what and how much you take...and i was taking a fair bit..so i wouldnt worry to much about your blood presure or heart rate going up to much..