I don't think you could comfortably grow 2 plants, start to finish, in a box this size. I started with with two until they got about 10 inches high and I could determine sexes:
At this stage, I had a divider in the top half of the cooler which allowed my lights to hang closer to the plant. See how low I have the lights in the following picture:
One turned out male, the other female. I killed the male, and shifted the female over to the center of the box. She grew up fast and then I took out the "compartment" of the cover-cooler and ran my lights direcly through the top, like you see in the next picture. This allowed an extra 6-7 inches room to the ceiling.
After that, instead of adjusting lights anymore, I just tied her to accomodate for the fixed positioning of my lights. That way she didn't get too close to the bulbs and all the buds got equal lighting. Here you can see the strings holding her down, and 1 plant pretty much filled up my box:
I hope this answers your questions, if you have anymore feel free to ask.