Yes, nutrients should be added at 300 ppm when the plant shows it first true sets of leaves.
Bigger seeds are kinda a yes and no answer, you do want a full developed seed and usually the bigger ones are maybe better developed.
You can determine sex a number of ways, wither by taking a cutting and rooting it and sexing it, of waiting for preflower which will generally apear after 30 days in veg.
Or you can flower the whole plant, and revert it to veg, although this method is highly unpractical..