Many and all research chemicals should be respected by the notion of unpredictability! It is true that a mg scale can relieve alot of the problems attributed to emergency hosptial visits or even death. Although, certain research chemicals have steep "dosage response curves," in which they are active and have a close resemblance to the extent of them being deadly. For example, 2ct7 taken orally is vastly different from insufflation... this comes into play because of the route of administration has changed... and orally their are different mediums of digestion that takes places... where the absorption rate of sniffing is much higher and the LD50 RATE is nearly cute in half. If you have the time, and are seriously interested in trying any research chemical you should read past trip reports not only contained in TIKHAL and PIKHAL... because most of those accounts are strict on their dosages due to safety and acknowledgment that indeed this is a research chemical that is being ingested. In most cases, the deaths that are documented on erowid.org are unnoted of the doses that are taken and lack alot of the material that is needed to make a theorized assesment for the cause of death then no other of the ingestment of a RC. Make known the facts and most experiences should be pleasurable for the most part!
. Another nice post bud, very true. 
