I think it's just the idea of one is grown naturally while the other is made by someone somewhere with who know what conditions. Don't get me wrong I've done both many times and they can both be really great or bad depending on your trip but now that I'm older I tend to gravitate toward shrooms because they usually last less time, and because they are easier to get when you not in that scene anymore. Try both at once, if you really want to experience something spectacular, be careful, and make sure you can tell yourself "I'm just tripping, this isn't real". Anyway, have fun, just be careful, I had a friend jump off a bridge once. He he lived and was fine but landed 3 feet from rebarb sticking out of the water and just about killed himself.