That question depends on many factors
primarily you need to allow for a change of air in your grow room at least once every 3-5 minutes. If you are running co2 you can have higher temperatures and thus running fan less is also possible, but if your temperatures struggle even during the night cycle it is a good idea to continue exhausting air.
your plants like the most stable environment possible, if your struggling with cold air you may need to either heat the room the tent is in so you can have a steady intake of consistent air or cool during the summer.
regardless of co2 or air temps you always need to circulate the air, so short answer is yes, but you could run it on a timer on/off