High CBD, Low Odor Medical Strain

Jogro

Well-Known Member
Erm:

OK, firstly, this isn't Brain Cancer, however, it is cancer... To wit:

Recent research on cannabidiol inhibiting breast cancer and clinical trials with cannabinoids
Did you even look at this link? First line:
Clinical trials with cannabinoids

Thank you for your interest in our research. Unfortunately, we are still trying to initiate clinical trials in order to test cannabidiol in humans for the direct treatment of metastatic cancer.
So sorry, no clinical research on cancer there.


Nope . . .that one doesn't describe clinical research either (ie actual tests on human beings with cancer).

Again, lab rat cancer models are not the same thing as tests on actual human beings with cancer.

And though the article'st title should read:
[h=2]"SPAIN STUDY CONFIRMS Cannabis OIL CURES CANCER WITHOUT SIDE EFFECTS", You get the drift:

http://www.endalldisease.com/spain-study-confirms-hemp-oil-cures-cancer-without-side-effects/[/h]
I think what this article's title should be is "credulous internet surfers will believe anything with big sciency words in it".

Again, no citation of clinical efficacy in treating human tumors AND the same article claims that sodium bicarbonate (ie baking soda) also cures cancer.

Which is pretty interesting, considering that bicarb is standard treatment for acidosis, and is widely given to all kinds of patients (including cancer patients) every day in every hospital in the USA. Like cannabis, you'd think if this actually cured cancer in the real world (rather than merely in the minds of quack medicine webpages), someone might have noticed by now.
 
I don't want to be a stick in the mud but

-There is zero clinical evidence that CBD, THC or any cannabinoid extract slows or stops brain cancer growth in human beings, and I'd say there are quite a few good reasons to think this is NOT true. At the risk of starting a flame war with the "true believers" if anyone reading this disagrees, feel free to post a link to a published research article showing different. I've looked into this quite extensively and so far as I can tell the science simply isn't there.

So, while this oil probably won't hurt, and may well give various kinds of symptomatic relief (pain, nausea, mood, appetite, etc), its probably not going to actually CURE the cancer.

-Before you go growing weed for your relative, I'd at least confirm that he and his immediate caretakers are open to the possibility of using it. . .they may not be and you well may be wasting your time. I say "immediate caretakers" because its likely that pretty soon your relative isn't going to be able to care for himself (assuming he even is now).

-There is more than one type of brain cancer, so its difficult to generalize, but assuming your relative has glioblastoma multiforme (which is the most common primary brain cancer), typical survival is about 12 months. . .in some cases its only a few months. If he has a different cancer that's spread to his brain (not true "brain cancer") then the prognosis may be a little better. . .though probably not all that much. The point is, the clock is ticking and you may not have a lot of time here to play around.

-Even if you planted your seeds first thing tomorrow morning, you wouldn't expect to have your harvest for ten weeks, and that's assuming absolutely minimal vegetative time. Add in time to acquire seeds, construction time for your grow area, learning curve, need for more vegetative growth to get a decent yield, time for drying curing, and you're probably not going to have an appreciable yield for four months. See above.

-Again, in my opinion, "Rick Simpson oil" is useful only for symptomatic relief of pain, but regardless of my opinion, if you actually want to make any appreciable amount of this oil for treatment purposes you'll need at least a POUND of buds, and several pounds would be better. This is not a "closet" operation.

To do that in one grow, you're going to need a massive grow room, which is a huge expense in time, money, labor, and legal risk. And with due respect, something like that probably is NOT suitable for a first time grower with zero experience.
1) Nobody is going to be able to quote a study about cannabis that proves much of anything because there isn't a wide variety of public information. Now, that's not to say that it doesn't exist - because we well know that official studies have been conducted. But because of cannabis' prohibition, the study of cannabis has been stymied. Further, there is virtually no research funding in cannabis, and independent research is obviously illegal, thus, there is no incentive for wide study. Therefore, the inability of people to cite studies that thoroughly demonstrate the viability of cannabis as a medicine is not because cannabis is inept at doing so, but solely because of legality.

Not citing a source does not, in itself, concede your point.

2) Roger Egeberg, M.D. is one of the main men responsible for Cannabis' classification as a schedule 1 drug. He thought it should be classified as such until the Nixon administration's National Commission on Marihuana and Drug Abuse concluded. After the commission concluded that the potential danger of marijuana usage was minimal, they recommended that the drug be LEGALIZED; however, the Nixon administration ignored their recommendation. It was then obvious that marijuana's illegality was being used more as a tool to reign in counter-culture, hippie, black-power, and other urban social movements (many of these movement's participants were known to regularly use marijuana). Notwithstanding, many federal studies were sanctioned during the subsequent period of time including the Compassionate Investigational New Drug program. This study set the precedent for marijuana as a medicinal alternative.

So, the science is there.

3) Humans produce cannabanoids, as they help the body regulate neurotransmitter function, including those that govern natural healthy cell function (Fride, Bergman, Kirkham 2005). As the body begins to have stress reaction to disease, it becomes difficult for the body to produce enough cannabanoids. Specifically in the case of cancer, where cancers overrun the immune system, this is a vital fact. Now, a monumental abundance of these same compounds that help regulate and modulate neurotransmitter and cell function are what make up plants in the cannabis family, hence the name. And that is the WBOA. By supplementing the body with cannabanoids, the body is able to regulate cell function with an uncanny efficiency. This gives the body the boost it needs to eliminate cancer cells in some cases.

Further, this plant accomplishes it's tasks by modulation and not inhibition. Pharmaceuticals accomplish their tasks by inhibition of natural biological function. With that said, it becomes obvious why cannabis is a great and sometimes more effective alternative to pharmacological medicines.

Again, the science is there.

4) There are many people out there who have experimented with different strains of marijuana and what I will tell you is that their medical effectiveness is not a unicorn. In some cases, you will see dramatic results. For instance, in pregnant women with uncontrollable nausea? I've seen that same nausea totally eliminated in seconds - sustainably. Other people have seen marijuana products help eliminate cancer.

So, just because you haven't seen this plant perform doesn't mean that the plant doesn't perform. Instead of agitating the Canna-Community be glad that you haven't needed the plant to solve a seemingly unsolvable medical ill.

In summation, I urge you to do more research so that you will, too, come to see what the big hoopla is all about.

WHO'S NEXT?!??!
 

st0wandgrow

Well-Known Member
I swear, when the letters "CBD" come up, it might as well be the full moon, suddenly the board is full of radiation oncologists and neurosurgeons. . .
Not even sure why I'm bothering, but this one is too choice to let go. . .


So cancer is caused by malnutrition? That's an interesting 1930s era hypothesis. . .its "refreshing" to see that people still believe it in this day and age.

For example, this explains why visceral cancers are rare in places where malnutrition is common, yet common in places where nutritional deficiencies are virtually unheard of. This also explains why so many people successfully cure their cancers with diet changes.


So cancer eats mucus and now you can cure cancer just by avoiding milk. Again, these are very "interesting" hypotheses. Ordinarily with claims these er. . ."unorthodox" I'd ask to see evidence, but in this case, I won't waste our respective time.


Indeed parasites are harmful to people with cancer. That's why we cook our food. . .


The human body is an "oxygenated environment", and actually since cancers are hypermetabolic, they use MORE oxygen than normal tissues.
Oh never mind. . .


Really? Employed by whom?


So its possible to eat meat, yet have it remain undigested in the intestines forever? That's interesting. Where does it "get stuck" and how does food you eat afterwards "slip by"?


Lets ignore for the moment the fact that cancer cells are just mutated human cells and have structurally similar membranes.

Could you please explain to me how digestive enzymes get free of the gut and make it to tumors and when this happens, why don't they just digest ordinary human tissue? This is fascinating stuff.
Ironically, you're the only one coming off like a complete know-it-all.

Have you treated many terminally ill patients? I'm dealing with 2 right now. Breast cancer survivor that now has bone cancer, and a patient with Dravets syndrome who has multiple seizures each and every day. My cancer patient is doing great. She's on a regiment of hemp oil and juicing with cannabis leaves daily. Her oncologist is amazed at her progress. She's on pace to be cancer free if things continue to trend in the same direction. My Dravets patient takes a high cbd vegetable glycerin dose through a feeding tube twice a day. He hasn't had a seizure in 17 days. Prior to using cannabis he had *never* gone a day without at least one seizure in the last 8 years.

I have no conclusive evidence to suggest that cannabis is the reason that these two are doing so well, but it would be one big fucking coincidence if it were anything otherwise.
 

bluntmassa1

Well-Known Member
Ironically, you're the only one coming off like a complete know-it-all.
.
LOL Don't you know Jogro knows everything just look at his posts not just on this subject either. dude is one smug individual god forbid science hasn't proved something they can't even test in the USA and many other countries around the world. But then your calling 100's if not 1,000's who claim it cured there cancer liars. Also I highly doubt it would be in the best interest for a pharmaceutical company foreign or domestic to prove it did cure cancer they make much more money on the treatment then they would on the cure if it were made by way of cannabis. so what you got smart to say about that Jogro?
 

Upstate2626

Well-Known Member
Back to the question- my Bodhi Good Medicine that I finished a couple of were semi-low order. Smoking a high cbd strain was new for me, gave a full plant to a girl I know that has fibro- she was very grateful. Not the tastiest strain but thats not its purpose.
 

st0wandgrow

Well-Known Member
LOL Don't you know Jogro knows everything just look at his posts not just on this subject either. dude is one smug individual god forbid science hasn't proved something they can't even test in the USA and many other countries around the world. But then your calling 100's if not 1,000's who claim it cured there cancer liars. Also I highly doubt it would be in the best interest for a pharmaceutical company foreign or domestic to prove it did cure cancer they make much more money on the treatment then they would on the cure if it were made by way of cannabis. so what you got smart to say about that Jogro?

That's an excellent point. These companies exist to make money, not to help people. We can't manufacture pills in our basement to treat our ailments, but we can all certainly grow marijuana. These companies, and by extension our government, have a vested interest in keeping marijuana and all of it's benefits in the shadows.
 

frogster

Active Member
The issue here is "cannabis cures cancer" ... good grief.. not unto itself........ there are determining factors involved,, like what is the person eating on a daily basis ( now vs before cancer spread to a noticible amount) If everyone ate a completely balanced , non toxic , nutrient rich "LIVING" food as God commmanded in Genesis without "STRESS" , anger , greed etc.. you get the point ... Marijuana is a FOOD that should be juiced for maximum benefits, before you get cancer out of control... TAKE NOTE: People are just as plants... find the deficiency , remove the object causing the deficiency and the "illness" will correct itself........... Balancing&correcting the human body with correct nutrients without adding toxins that will disrupt the potential of the growth cycle of a human is a little more advanced than a plant in a hydroponic system,,,,,,,, Lighten up Jorge.......
 

Jogro

Well-Known Member
Have you treated many terminally ill patients?
This isn't about me. Please explain to me what this has to do with whether or not cannabis cures cancer, and then I'll happily answer.

I'm dealing with 2 right now. Breast cancer survivor that now has bone cancer, and a patient with Dravets syndrome who has multiple seizures each and every day.
Never said cannabis couldn't help with seizures, I said there was no evidence it cured human cancers. There is a BIG difference between these two things. There is also a big difference between helping with SYMPTOMS of cancer (which I've already acknowledged multiple times in this thread), and CURING it.

My cancer patient is doing great. She's on a regiment of hemp oil and juicing with cannabis leaves daily. Her oncologist is amazed at her progress. She's on pace to be cancer free if things continue to trend in the same direction.
Glad to hear she's doing well, but since you're admitting that your cannabis hasn't cured her cancer, I'm not sure how this example disproves my point.

LOL Don't you know Jogro knows everything just look at his posts not just on this subject either. dude is one smug individual god forbid science hasn't proved something they can't even test in the USA and many other countries around the world.
Again, this isn't about me.

I don't think I know everything, but I do know that medical cannabis is now legal in 20 US States, and in many of them anyone with cancer can walk into a dispensary and walk out with as much cannabis as they need. So contrary to what you are suggesting above, there is absolutely NOTHING stopping tens of thousands of cancer patients, or their doctors from "testing" cannabis, if they choose to. There is also nothing preventing any MD from publishing case reports of any cure they believe has occurred because of cannabis therapy.

If cannabis is effective at curing cancers, why aren't the airwaves filled with reports of these "miracle" cures from these places? If, for example, cannabis is effective at curing breast cancer, why hasn't this information become widely known in cancer therapy and "survivor" circles in CA, and why do women there continue to die of breast cancer there?

But then your calling 100's if not 1,000's who claim it cured there cancer liars.
No; you're simply putting words in my mouth. Suppose I were to find you thousands of people who sincerely believe that prayer or diet cured their cancers. Would that make it true?

Why don't you show me a few before and after MRIs of these cancers that have been "cured" with cannabis? If these cures are as prevalent as you claim, you shouldn't have any problem finding this evidence. Do that, and then we can talk about the differences between truth and belief.

Also I highly doubt it would be in the best interest for a pharmaceutical company foreign or domestic to prove it did cure cancer they make much more money on the treatment then they would on the cure if it were made by way of cannabis. so what you got smart to say about that Jogro?
I'd say that you overlooked my multiple earlier posts in this thread addressing this very issue.

It doesn't make a bit of difference what the drug companies "want" or don't want. If it were actually true that cannabis could cure cancers, there really isn't a damn thing they could do to stop people from finding out about this, or obtaining as much cannabinoids as they needed. Proof doesn't need to come from the drug companies, and it isn't even expected to.

The fact is, if cannabis could cure cancer, people are going to use it to cure cancer. The drug companies have ZERO ability to stop people from doing this, and frankly neither can the gov't. Think about this for a moment. If people are willing to risk serious jail time just to grow/sell/smoke cannabis to get high for a few hours, don't you think they'll do it to save their own or family members lives from cancer? Despite what crackpots on the internet suggest, if cannabinoids did cure cancers, then neither drug companies nor the gov't couldn't suppress this sort of information, especially in the internet age where anyone can make information instantly globally available from their living room.

Either cannabis is effective at curing cancer, or it isn't. Considering how readily available cannabis is (especially in medical states), then if this were true, then every cancer clinic in the country would be full of people with "miracle" cancer cures, and there would be crops of young oncologists in legal states curing all their patients with cannabinoids every single day. Cancer death rates would plummet in legal states as patients learned about effective therapies, cannabis-heavy oncology clinics sprung up, and sick pts obtained cannabinoid remedies for themselves. But none of these things have happened. Why not?

If drug companies (and/or the govt) have somehow suppressed the knowledge that cannabis can cure cancer, then how are we talking about it in a public forum?

On drug companies, if cannabis actually could cure cancers, then the ONLY thing the drug companies would want to do is to get in the cannabis anti-cancer business themselves. There would be TONS of money to be made selling standardized cannabinoid extracts of pre-determined and consistent potency, and the drug companies would *LOVE* to get in on that business. That's how the free market operates. Again, drug companies make money selling ASPIRIN tablets at a fraction of a cent each. Why wouldn't they be able to make money selling highly specialized, pharmaceutical grade cannabinoid products optimized for curing cancers?

In fact, not only would they want to get involved in selling for-profit cannabis-based medicines themselves they'd really have no choice, because if they didn't do it, the competition would, and would hurt their bottom lines. If none of the existing drug companies wanted to touch cannabinoids, then new ones would form and drive them out of business.

Of course the drug companies that make anti-cancer drugs might see some loss in sales if other effective therapies emerged. . .but so what? This is a NORMAL occurrence in the drug industry. Older products lose patent protection and other companies come out with cheap generics and take their market share. Over time better classes of drugs emerge and older ones fall out of the marketplace. That happens all the time. Ask any drug company representative if they think their current "hot" anti-cancer molecule will still be in use in even 15 years, and they'll tell you they doubt it. The nature of the anti-cancer drug marketplace is always changing; if cannabinoids could cure cancers, this would just be one more change.

Bottom line, invoking drug company conspiracy to suppress evidence of cannabis efficacy doesn't explain a lack of evidence, and it just doesn't make sense. Drug companies don't act in concert; they all compete against one another and any new product that took market share from one company would only help another one. Drug companies are always looking for the next big product; if cannabinoids could cure cancers, they'd want to exploit that, not try (and inevitably fail) to suppress it.

That's an excellent point. These companies exist to make money, not to help people. We can't manufacture pills in our basement to treat our ailments, but we can all certainly grow marijuana. These companies, and by extension our government, have a vested interest in keeping marijuana and all of it's benefits in the shadows.
With due respect, I think you've got this backwards. Drug companies cannot make money UNLESS they help people. If there is no demand for their product, they go out of business, and with very few exceptions, there isn't a lot of demand for drugs that don't work. Even stipulating that cannabis is great medicine for a great many things, its not going to replace every product on the pharmacy shelves. That's ridiculous. At best it might replace a FEW of them, and it may also provide alternatives to a few more (which will still exist, just with smaller market share). Cannabis simply poses no threat to the vast majority of drugs put out by the vast majority of drug companies.

On Gov't, we also live in a democracy, and "the gov't" responds to the will of the people. Perhaps imperfectly. . .but it still does. I "get" the concept of a war on drugs, but what "interest" does our gov't have in ensuring that people die unnecessarily of cancer? There are plenty of slimeballs out there on both sides of the aisle, but can you name even one politician whom you think would vote to suppress a cancer therapy with proven effectiveness? Again, if "the gov't" is so interested in suppressing cannabis as cancer therapy, then how come the number of cannabis-legal medical states expands every year? Seems to me like whatever grip "the gov't" had on suppressing cannabis is only continuing to loosen.
 

tekdc911

Well-Known Member
Again, I don't want to be a wise-ass here, but if you really believe this to be true, please cite one.

I haven't seen any clinical studies in human beings with cancer showing survival benefit with cannabinoid therapy (let alone widely metastatic cancer).


.
http://en.wikipedia.org/wiki/Cannabidiol
check the wiki out bud


and to the OP have you looked into any autoflower strains ? fairly easy to grow high cbd for the most part
 

Jogro

Well-Known Member
1) Nobody is going to be able to quote a study about cannabis that proves much of anything because there isn't a wide variety of public information. Now, that's not to say that it doesn't exist - because we well know that official studies have been conducted. But because of cannabis' prohibition, the study of cannabis has been stymied. Further, there is virtually no research funding in cannabis, and independent research is obviously illegal, thus, there is no incentive for wide study. Therefore, the inability of people to cite studies that thoroughly demonstrate the viability of cannabis as a medicine is not because cannabis is inept at doing so, but solely because of legality.
Lets be clear here. The incentive to proving that cannabis (or any other agent) can cure human cancers is massive and should be self-evident.

The inability of anyone to cite a prospective study proving the efficacy of cannabis in shrinking human tumors is because no such study exists.

Again, while it would be nice to hold cannabis cancer therapy to the same standards as every OTHER cancer therapy, with respect to prospective study of efficacy, I'm not even asking for that level of proof.

It costs NOTHING to publish a case report of a tumor response of any cancer attributable to cannabinoids. No drug company has "veto power" over any such case report. Neither does any government agency; publishing that kind of report not only isn't illegal, many physicians would consider it an absolute moral imperative to publish case reports like that from a public health perspective. Certainly there are all sorts of academic physicians looking for things to publish. . ."cancer cure" case reports being about as close to the holy grail as you're going to find in medicine.

This type of case report/series doesn't even require IRB board approval. Any clinician publishing a report like this wouldn't even have to prescribe or administer the drug. The only thing they'd have to do is to notice that one (or better yet, several) of their cancer patients who self-administered State legal cannabinoids in a medical state had an otherwise unexplained response. then publish the findings. If any physician got wind of something like this, there would be a STRONG incentive to publish it.

That is a VERY low bar to provide some good evidence of a real-world anti-cancer effect in human beings by cannabis. So why hasn't this been done?

Not citing a source does not, in itself, concede your point.
Sure, absence of evidence isn't evidence of absence. The fact that I can't produce a carcass of a Bigfoot doesn't mean they don't exist.

But the burden of proof here is on the ones making the cure claim, not on me. Lacking good evidence to support the claim that cannabis cures cancer, the only fair assumption is that its not true.

As explained above, if hemp oil (or whatever extract) were really a "miracle cure" this would be TRIVALLY EASY to show, with no need for grants, IRBs, gov't or drug company approval, etc. All you'd need are before and after MRIs or CT scans from someone with terminal cancer who was cured. The fact that nobody has shown anything like this by itself doesn't by itself mean its impossible, but given the widespread use of cannabis in places like CA, CO, etc, among cancer patients, the strong presumption should be that if this sort of thing EVER happened, someone in the medical community would have noticed and published it by now.

2) Roger Egeberg, M.D. is one of the main men responsible for Cannabis' classification as a schedule 1 drug. He thought it should be classified as such until the Nixon administration's National Commission on Marihuana and Drug Abuse concluded. After the commission concluded that the potential danger of marijuana usage was minimal, they recommended that the drug be LEGALIZED; however, the Nixon administration ignored their recommendation. It was then obvious that marijuana's illegality was being used more as a tool to reign in counter-culture, hippie, black-power, and other urban social movements (many of these movement's participants were known to regularly use marijuana). Notwithstanding, many federal studies were sanctioned during the subsequent period of time including the Compassionate Investigational New Drug program. This study set the precedent for marijuana as a medicinal alternative.

So, the science is there.
Sorry, is there some part in there relevant to a cancer cure in humans with cannabis?

3) Humans produce cannabanoids, as they help the body regulate neurotransmitter function, including those that govern natural healthy cell function (Fride, Bergman, Kirkham 2005). As the body begins to have stress reaction to disease, it becomes difficult for the body to produce enough cannabanoids. Specifically in the case of cancer, where cancers overrun the immune system, this is a vital fact. Now, a monumental abundance of these same compounds that help regulate and modulate neurotransmitter and cell function are what make up plants in the cannabis family, hence the name. And that is the WBOA. By supplementing the body with cannabanoids, the body is able to regulate cell function with an uncanny efficiency. This gives the body the boost it needs to eliminate cancer cells in some cases. Further, this plant accomplishes it's tasks by modulation and not inhibition. Pharmaceuticals accomplish their tasks by inhibition of natural biological function. With that said, it becomes obvious why cannabis is a great and sometimes more effective alternative to pharmacological medicines.

Again, the science is there.
Again, I seem to have missed the part where you provided any evidence to support your assertion about cancer cure. Saying "the science is there" by itself doesn't actually prove anything. You say there are "some cases" where cannabinoids can help eliminate human cancers. Would you care to cite a specific case of an actual human being where this has been shown to be true? If you can't do this, what do YOU think the appropriate conclusion is?

4) There are many people out there who have experimented with different strains of marijuana and what I will tell you is that their medical effectiveness is not a unicorn. In some cases, you will see dramatic results. For instance, in pregnant women with uncontrollable nausea? I've seen that same nausea totally eliminated in seconds - sustainably. Other people have seen marijuana products help eliminate cancer.
Nobody disputes that cannabis can relieve nausea, or have other beneficial medical effects. Whether or not that's the best agent for use in pregnant women is a different question, but that's not really the question here.

Hearsay reports of cancer cures are, medically speaking, roughly equivalent to stories of bigfoot sightings.

So, just because you haven't seen this plant perform doesn't mean that the plant doesn't perform. Instead of agitating the Canna-Community be glad that you haven't needed the plant to solve a seemingly unsolvable medical ill.
Again, this isn't about me, or what I have or haven't seen, nor is it about my particular medical needs. I'm also not the one doing the agitation here.
You made a specific claim about cannabis curing cancer.
If you don't have good evidence to back up this assertion, that's OK, but the intellectually honest thing to do is simply to say so.

In summation, I urge you to do more research so that you will, too, come to see what the big hoopla is all about.
So, in summation, you have no evidence to back your assertion about cannabis and cancer.
I've actually done a fairly thorough review of the literature already, thanks. If you believe I've missed some key bit of clinical evidence, please educate me.

In the meantime, again for the nth time, I have no problem with cancer patients using cannabis responsibly for medical purposes; they can get all sorts of (proven) benefits from it. But lacking objective real-world evidence for tumor shrinking effects, I think its simply not reasonable to expect a "cure".
 

tekdc911

Well-Known Member
[h=3]Cancer research[edit source | editbeta][/h]In November 2007, researchers at the California Pacific Medical Center reported that CBD shows promise for controlling the spread of metastatic breast cancer. In vitro CBD down-regulates, or "turns off", the activity of ID1, the gene responsible for tumor metastasis[SUP][12][/SUP] in breast and other types of cancers, including the particularly aggressive triple negative breast cancer.[SUP][12][/SUP][SUP][27][/SUP][SUP][28][/SUP]The researchers in September 2012 said they hope to start human trials soon.[SUP][29][/SUP]
Cannabidiol has been shown to inhibit cancer cell growth with low potency in non-cancer cells. Although the inhibitory mechanism is not yet fully understood, Ligresti et al. suggest that "cannabidiol exerts its effects on these cells through a combination of mechanisms that include either direct or indirect activation of CB[SUB]2[/SUB] and TRPV1 receptors, and induction of oxidative stress, all contributing to induce apoptosis."[SUP][28][/SUP]
Non-psychoactive cannabinoids, including cannabidiol (CBD) and other more pronounced CB[SUB]2[/SUB] agonists such as cannabinol (CBN, an immunosuppressant), are now seen as promising targets for anti-tumor drugs since they experimentally reduce the size of in-vivo xenografts, for example gliomas. Combinations of submaximal THC doses and CBD have both been successfully applied to greatly increase in-vitro efficacy of temozolomide in glioblastoma multiforme cell lines. CBD likely exerts its effects through the induction of apoptosis by Reactive oxygen species.[SUP][30][/SUP] Non-psychoactive cannabinoids can be administered at much higher doses without the well-known side effects that are sometimes associated with the drop-out rate in trials involving psychoactive cannabinoids.
A team of researchers from the University of California at Irvine proposed in February 2013 that CBD's anti-malignant effect by way of apoptosis may be due to its potential action on "mutant p53 proteins in cancer cells," due to cannabidiol's chemo-physical similarity to stictic acid, a promising anti-cancer compound found in some species of lichens that acts on the aforementioned proteins. The University biologists, chemists and computer scientists "identified an elusive pocket on the surface of the p53 protein that can be targeted by cancer-fighting drugs".[SUP][31][/SUP][SUP][32]

quoted from http://en.wikipedia.org/wiki/Cannabidiol[/SUP]
 

st0wandgrow

Well-Known Member
"On Gov't, we also live in a democracy, and "the gov't" responds to the will of the people. Perhaps imperfectly. . .but it still does. I "get" the concept of a war on drugs, but what "interest" does our gov't have in ensuring that people die unnecessarily of cancer?"



Jogro, you have to be kidding me. The short answer is MONEY!! Why is our government OK with allowing the sale of and taxing cigarettes, which we not only know they add addictive chemicals to, but we also know will kill us? We can smoke cigarettes until we kill ourselves, and drink ourselves in to a coma, but weed is bad? Even in the face of overwhelming evidence to the contrary? Why do we continue to burn fossil fuels when there is cleaner technology out there? Why do we continue to increase the defense budget when we have a 15 trillion dollar national debt?

If you haven't clued in to the fact that our government is in bed with corporate America, and there is a revolving door between DC and oil companies, pharmaceutical companies, insurance companies, etc then I don't know what else to say to you. If this comes as a newsflash, just take a look at how many former Monsanto executives are now heading up departments like the FDA.

If marijuana were proven to be a more effective treatment for a disease like cancer, do you know how much money these companies would stand to lose .... and by extension how much campaign loot our elected officials would lose? Billions. Probably trillions. These companies don't care about you or I. They care about profit.

Having said all of that, we do not have any conclusive proof that marijuana can cure cancer. But if you think for one minute that our government isn't actively trying to keep it that way, then you are sorely misinformed.
 

st0wandgrow

Well-Known Member
The issue here is "cannabis cures cancer" ... good grief.. not unto itself........ there are determining factors involved,, like what is the person eating on a daily basis ( now vs before cancer spread to a noticible amount) If everyone ate a completely balanced , non toxic , nutrient rich "LIVING" food as God commmanded in Genesis without "STRESS" , anger , greed etc.. you get the point ... Marijuana is a FOOD that should be juiced for maximum benefits, before you get cancer out of control... TAKE NOTE: People are just as plants... find the deficiency , remove the object causing the deficiency and the "illness" will correct itself........... Balancing&correcting the human body with correct nutrients without adding toxins that will disrupt the potential of the growth cycle of a human is a little more advanced than a plant in a hydroponic system,,,,,,,, Lighten up Jorge.......

So marijuana won't do the trick, but if you eat your broccoli you'll live forever.

Sounds reasonable.
 

bluntmassa1

Well-Known Member


  • It doesn't make a bit of difference what the drug companies "want" or don't want. If it were actually true that cannabis could cure cancers, there really isn't a damn thing they could do to stop people from finding out about this, or obtaining as much cannabinoids as they needed. Proof doesn't need to come from the drug companies, and it isn't even expected to.

    The fact is, if cannabis could cure cancer, people are going to use it to cure cancer. The drug companies have ZERO ability to stop people from doing this, and frankly neither can the gov't. Think about this for a moment. If people are willing to risk serious jail time just to grow/sell/smoke cannabis to get high for a few hours, don't you think they'll do it to save their own or family members lives from cancer? Despite what crackpots on the internet suggest, if cannabinoids did cure cancers, then neither drug companies nor the gov't couldn't suppress this sort of information, especially in the internet age where anyone can make information instantly globally available from their living room.​




Jesus dude you wright posts like old hazey grapes 2 page posts you know aint nobody reading through. The truth is the government and big businesses are a lot grimier than you believe its also been proven effective in lab rats and there are people who use it to cure cancer and there are a lot of people that swear it worked really everything in this second paragraph here is being done and the information is there. Just not a government/scientific test on humans yet their are many underground tests where they have the freedom of not giving a fuck about the law or the corporations funding them they have only the patient to make happy. sure not everyone believes it I don't even believe it will work for every cancer but why tell people its bullshit if you had a close family member whither away slowly from cancer you would try it too. Its by far worth the try is it not? have you lived with someone with cancer? fuck no you haven't other wise you wouldn't come off as such a smug prick you'd tell people to give it a try its not like its gonna kill them and that hope may just help them if the hash oil don't.

so why argue? you don't know it won't cure cancer nobody knows except maybe Rick Simpson and a few others but why would they lie? what do they have to gain? you don't think governments and/or scientists never covered shit up you are naive they are allowed to test cannabis in this country but no positive findings can be published you don't think a big time chemo manufacturer wouldn't pay to disprove it will cure cancer?
 

Jogro

Well-Known Member
[h=3]Cancer research[edit source | editbeta][/h]In November 2007, researchers at the California Pacific Medical Center reported that CBD shows promise for controlling the spread of metastatic breast cancer. In vitro CBD down-regulates, or "turns off", the activity of ID1, the gene responsible for tumor metastasis[SUP][12][/SUP] in breast and other types of cancers, including the particularly aggressive triple negative breast cancer.[SUP][12][/SUP][SUP][27][/SUP][SUP][28][/SUP]The researchers in September 2012 said they hope to start human trials soon.[SUP][29][/SUP]
Cannabidiol has been shown to inhibit cancer cell growth with low potency in non-cancer cells. Although the inhibitory mechanism is not yet fully understood, Ligresti et al. suggest that "cannabidiol exerts its effects on these cells through a combination of mechanisms that include either direct or indirect activation of CB[SUB]2[/SUB] and TRPV1 receptors, and induction of oxidative stress, all contributing to induce apoptosis."[SUP][28][/SUP]
Non-psychoactive cannabinoids, including cannabidiol (CBD) and other more pronounced CB[SUB]2[/SUB] agonists such as cannabinol (CBN, an immunosuppressant), are now seen as promising targets for anti-tumor drugs since they experimentally reduce the size of in-vivo xenografts, for example gliomas. Combinations of submaximal THC doses and CBD have both been successfully applied to greatly increase in-vitro efficacy of temozolomide in glioblastoma multiforme cell lines. CBD likely exerts its effects through the induction of apoptosis by Reactive oxygen species.[SUP][30][/SUP] Non-psychoactive cannabinoids can be administered at much higher doses without the well-known side effects that are sometimes associated with the drop-out rate in trials involving psychoactive cannabinoids.
A team of researchers from the University of California at Irvine proposed in February 2013 that CBD's anti-malignant effect by way of apoptosis may be due to its potential action on "mutant p53 proteins in cancer cells," due to cannabidiol's chemo-physical similarity to stictic acid, a promising anti-cancer compound found in some species of lichens that acts on the aforementioned proteins. The University biologists, chemists and computer scientists "identified an elusive pocket on the surface of the p53 protein that can be targeted by cancer-fighting drugs".[SUP][31][/SUP][SUP][32]

quoted from http://en.wikipedia.org/wiki/Cannabidiol[/SUP]
Just as clarification for those who may not understand, "in vitro" means in test tubes.

Nowhere in that is any evidence of real-world effect on actual human beings. The only thing it says is that since there is some effect in test tubes, they'd like to test it in actual cancer patients (ie clinical trials).
 

Jogro

Well-Known Member
"
Having said all of that, we do not have any conclusive proof that marijuana can cure cancer.

I don't even need "conclusive proof", I just want *some evidence* it works in people. I don't really think that's too much to ask for, and I respect the fact that you can admit this.

Now that you concede that there isn't good evidence of this, how responsible do you think it is to tell cancer patients that cannabis can cure their cancer? Is that a "fair" thing to do? If you believe in medical marijuana, do you think its GOOD for the movement, or BAD to the movement to attribute unproved, near magical powers to the drug?

But if you think for one minute that our government isn't actively trying to keep it that way, then you are sorely misinformed.
Please spare me "The Man is Keeping us Down" conspiracy theories. There is no such thing as "the gov't".

There is municipal gov't, county gov't, state gov't, and Federal gov't, and not only do these different levels not always get along with each other, they often don't even get along within the same level.

If "our gov't" is so united against medical cannabis, why has it been legalized for medical use in 20 states in the last 10 years? State politicians are less corrupt than Federal ones?

Again, the quick answer is that in a democracy like ours public policy responds to public opinion. It may happen slowly, but it happens.

If you track the public opinion polling, the public was majority AGAINST legalizing cannabis just ten years ago, but every year in that time, the scale has shifted slowly, slowly, slowly to the pro-cannabis position to the point where now there is a narrow majority supporting it. Once that majority becomes big enough, and enough States tip over to decriminalized or medical models, Federal policy will change. Hard to predict an exact date, but the way things are going, its probably going to happen within ten years time.

Its the exact same thing as Gay marriage. Twenty years ago, not only was there was no such thing as legal same-sex marriage, nobody was even seriously talking about it. Now its legal in a number of states. Why? Was "the gov't" suppressing gay marriage as a social issue? No. . .the gov't response to the will of the voters on things like this. In the last 20 years there has been tremendous amounts of gay activism and the rise of a younger generation of voters, and gov't policy has shifted in response to public opinion here.
 

st0wandgrow

Well-Known Member
"Now that you concede that there isn't good evidence of this, how responsible do you think it is to tell cancer patients that cannabis can cure their cancer? Is that a "fair" thing to do? If you believe in medical marijuana, do you think its GOOD for the movement, or BAD to the movement to attribute unproved, near magical powers to the drug?"



I don't tell anyone anything. They sought my help. This was their choice. And I don't feel it's any less responsible than the "magical powers" that we currently attribute to chemotherapy and radiation. At a minimum the marijuana regiment has some positive side effects such as stimulated appetite, better rest and stress relief .... unlike our conventional treatments that leave people zapped of energy and appetite due to the shit that they pump people full of that does not discriminate between cancer cells and healthy cells.

Did you catch Dr Sanjay Gupta's special on CNN? There is a hospital in Israel that is studying the positive effects of marijuana in treating cancer patients. They seem optimistic. What a bunch of fools, eh?

At any rate, this horse has been thoroughly flogged. We'll have to agree to disagree.
 

Jogro

Well-Known Member
Jesus dude you wright [SIC] posts like old hazey grapes 2 page posts you know aint nobody reading through. The truth is the government and big businesses are a lot grimier than you believe its also been proven effective in lab rats and there are people who use it to cure cancer and there are a lot of people that swear it worked really everything in this second paragraph here is being done and the information is there. Just not a government/scientific test on humans yet their are many underground tests where they have the freedom of not giving a fuck about the law or the corporations funding them they have only the patient to make happy. sure not everyone believes it I don't even believe it will work for every cancer but why tell people its bullshit if you had a close family member whither [SIC] away slowly from cancer you would try it too. Its by far worth the try is it not? have you lived with someone with cancer? fuck no you haven't other wise you wouldn't come off as such a smug prick you'd tell people to give it a try its not like its gonna kill them and that hope may just help them if the hash oil don't.
With due respect, you haven't the foggiest clue how many family members and/or friends of mine have died of cancer, and you're WAY out of line with this. The name calling and personal insults just prove you have nothing meaningful to say.

If sick people want to gamble with experimental/unproven therapies, so long as they're aren't lied to and understand the risks, I don't have any problem with it. But making unsubstantiated (and in some cases on their face ridiculous) claims about cannabis as a miracle cure for cancer not only potentially hurts sick patients, it turns the entire legitimate medical cannabis movement into a laughingstock.

Maybe that doesn't matter to you, but I think it should matter to people who want to get the best possible benefit from cannabis as medicine.

so why argue? you don't know it won't cure cancer
I've just explained why I care about this.

I also can't prove that Bigfoots don't exist, and this is the exact same thing.

We've seen quite a bit of talk about miracle cancer cures with cannabinoids, and a lot of cancer patients using them (legally and openly) all over the world, but when it comes down to it, nobody can actually come up with a single medically documented case of a cannabis related cancer cure. Why not?

nobody knows except maybe Rick Simpson and a few others but why would they lie? what do they have to gain?
You really don't understand why quacks and snake oil salesmen exist, and how they profit from this sort of thing?

you don't think governments and/or scientists never covered shit up you are naive they are allowed to test cannabis in this country but no positive findings can be published you don't think a big time chemo manufacturer wouldn't pay to disprove it will cure cancer?
These conspiracy theories don't hold up to common sense or reality.

First of all, there is plenty of literature on medical benefits of cannabis. . .just not cancer cures. So this theory about drug companies suppressing positive findings is false on its face.

Second, the maker of Sativex, GWPharm, is actively conducting research on cannabinoid therapy and publishing positive results, contradicting your premise about drug companies suppressing positive results. Why? Because they stand to make boatloads of cash if they can prove that their cannabis based drug is clinically useful. Again, this idea that drug companies are afraid of cannabis is false on its face. If the legal status of cannabinoid research changed, you'd sell a hell of a lot MORE of this kind of thing from the big phamaceutical houses.

Next, assuming he/she could actually document one, there is NOTHING stopping any cancer doctor from publishing a case report on a proven cancer cure tomorrow, even on their own personal blog, if they wanted to. How on earth is a drug company going to stop that? Hell. . .how would they even know about it until after it happened?

The very idea that drug companies have "veto power" over what gets published in every single scientific or medical journal on the planet is cuckoo-talk. The fact is that major anti-drug studies appear in major medical journals ALL THE TIME, and I can think of at least several major "blockbuster" type drugs that were pulled off the market because of these sort of things, causing millions of dollars of lost sales for these companies. Empirically, drug companies have never really been able to suppress research that hurt their products marketability, and they probably never will. If they can't do it to protect their blockbuster anti-inflammatory drugs (for example), then how are they going to be able to do it with anti-cancer drugs, which represent a far smaller market?

Also, its not like publishing in journals is the only way to get these things out. Important clinical findings can also be presented in abstract form at conferences (which drug companies have no control over either), and shared in person between physicians. Someone with good evidence could make a case at any of these venues and there wouldn't be anything a drug company could do to stop it. Again, there would literally be no way they could possibly even know about it until after it happened.
 

Jogro

Well-Known Member
I don't tell anyone anything. They sought my help. This was their choice. And I don't feel it's any less responsible than the "magical powers" that we currently attribute to chemotherapy and radiation.
Nobody is claiming magic powers for radiation or chemotherapy.

The most important difference there is that there is BOATLOADS of evidence that both conventional chemotherapy and radiation therapy shrink tumors, prolong lives, and yes, even cure cancers. No, not all cancers, but plenty of them. I've seen these things with my own eyes, many times, and if you care to, you can spend months reading studies looking at real world effects of these things in cancer patients.

With cannabis chemotherapy. . .not so much.

At a minimum the marijuana regiment has some positive side effects such as stimulated appetite, better rest and stress relief .... unlike our conventional treatments that leave people zapped of energy and appetite due to the shit that they pump people full of that does not discriminate between cancer cells and healthy cells.
Yes, cannabis is good for symptomatic relief, and it can play a role in the overall management of cancer cases. But treating symptoms isn't the same as shrinking tumors, and its an important distinction.

Would you rather feel "zapped of energy" after radiation or chemotherapy, or die horribly from metastatic disease? Chemo may be "shit" but its shit that kills cancers and saves lives. Surely you're not suggesting that cancer patients should skip the effective, but unpleasant rad/chem therapies and just go with cannabis alone?

Did you catch Dr Sanjay Gupta's special on CNN? There is a hospital in Israel that is studying the positive effects of marijuana in treating cancer patients. They seem optimistic. What a bunch of fools, eh?
To be clear, hospitals don't study things. . .researchers do, and of course they're optimistic, every cancer researcher is.

Are any of these Israeli researchers actually claiming they can shrink tumors with cannabis therapy? Somehow, I don't think so.

We'll have to agree to disagree.
Since you've conceded that there is currently no good evidence that cannabis cures human cancers, and I've said way in my first posts in this thread that cannabis is good for treating symptoms of cancer, I don't even think we do disagree.

This just comes down to expectations.

Cannabis can be good medicine, but just because its great for SOME things, doesn't mean its great for EVERYTHING. Medical cannabis is already a "punchline" all by itself; I don't think its good for patients, caregivers, doctors, or the movement for advocates to make unsubstantiated claims about efficacy, especially in life-or-death situations. Couple fantastical claims about efficacy with risible claims about conspiracies, or couple them with other crackpot medical beliefs . . .well, now you're just reinforcing negative stereotypes about recreational cannabis use.

Perhaps one day someone will be able to shrink certain types of tumors with some sort of synthetic cannabinoid mix, or find that it can be used in that role as an adjunct. As mentioned many times upthread, there are some clues in animal models and in-vitro cancer cells lines, so this is certainly plausible. But right now, nobody seems to be able to do it.
 
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