I could probably give you a good answer here as I am very sensitive to any drugs...not just cannabis. Cannabis Sativa is more of a nice laughy high for me...I prefer it actually but it is harder to come by in these parts since it is less of a "trippy visual head high". Dealers and Growers in Eastern Canada prefer Cannabis Indica as it is more of a balls out experience, rather uncontrollable when it comes to effects. And those who are younger or more willing to explore the "let's see what happens" factor, "let's get smashed"...etc. etc. are buying Indica. So an Indica mix is what you are most likely to find. However, mostly Sativa mix with a little Indica is fine with me. I prefer happiness over anxious panic or an uncontrollable high...just my thing. I had a heart attack due to stress at 34...so more happy and giddy the better. I admit, back in the day...I loved getting shit faced stoned and the more I was out of control of my bodily functions, the better...hey, I wanted my money's worth. It just depends on what you prefer...but yes, there is a big difference. Indica to Sativa...strain to strain.
Green Outlaw