I've only done it in small doses. Enough for me to get giggly and have a heavy bodily drunk (but not drunk, heh) feeling. Which is pretty fun for me haha.
I don't mind psychedelics or whatever (i haven't done them all though), but I don't like the feeling of losing control of my body and/or actions. Which seems to be how a lot of people feel.. I feel like I've read about too many people having bad trips that i'm paranoid that i will have a bad one, which is convincing me that I really will have one. Which is making me stay away from it. haha