I keep my intake (which is powered) bringing in air from outside 24/7. My exhaust + filter is on a timer, an hour after lights out it comes on only 15 min per hour, my oscillating fan does the same. Personally I've experienced no issues, but everyone's grow is different. My area is not sealed. Plants from what I've seen tend to kick off a lot of smell just after lights out so you'd definitely want your fans running then.