A picture speaks 1000 words.
Set it up loosely relative to this:
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I also wouldnt vent the air into your attic, just the same as you wouldnt do it for a shower room. Find a vent in your attic/crawlspace which most homes with attics have to vent out of or tap into your chimney stack if possible. Do you have a bathroom fan that vents outside? Find that vent and tap into it.
There should be at least one of a few ways to vent properly.
More words of caution:
Make sure you will be setting your portable A/C unit and your lighting (specially HID lighting) and fans etc on a circuit that can handle the load -cautious it isnt branced off by 3 other circuits on a 15 A breaker with other things from other rooms plugged into it. It will draw a lot of juice and stuff can get hot if it isnt rated for that kind of load.
Dont have anything electrical on the ground. Get all plugs/ extention cords/adapters etc off the floor. Set up like an aquarium with drip loops on everything.
Be safe.