Random Jabber Jibber thread

Caffeine dosing strategies to optimize alertness during sleep loss
https://onlinelibrary.wiley.com/doi/full/10.1111/jsr.12711

I saw the headline and thought, yeah, maybe something to it. but before you have your first cuppa, figure this out. lol

jsr12711-math-0001.png


where Z denotes the objective function that we wish to minimize. The optimization variables ti and Di represent the time (in hours after the first wake‐up time in the schedule) and the caffeine amount (in mg) of dose i, respectively, with i = 1, 2, …, n (the number of doses). AUC denotes the area under the PVT mean response time (RT) curve above the baseline, and WP the difference between the peak of the mean RT curve and the baseline. C(ti, Di) denotes the level of caffeine in the blood. The subscripts C and NC denote caffeine and no caffeine, respectively. The last term penalizes the objective function when the maximum value of C(ti, Di) is higher than the maximum caffeine level achieved by a single dose of 400 mg, denoted by Cmax.
 
Anthony Bourdain dead at 61.

The travel host Anthony Bourdain, whose memoir “Kitchen Confidential” about the dark corners of New York’s restaurants started a career in television, died on Friday at 61.

For the past several years, Mr. Bourdain hosted the show “Parts Unknown” on CNN and was working on an episode in Strasbourg, France, when he died, the network said Friday morning. He killed himself in a hotel room, the network said.

https://www.nytimes.com/2018/06/08/...-bourdain-dead.html?smtyp=cur&smid=tw-nytimes
 
Caffeine dosing strategies to optimize alertness during sleep loss
https://onlinelibrary.wiley.com/doi/full/10.1111/jsr.12711

I saw the headline and thought, yeah, maybe something to it. but before you have your first cuppa, figure this out. lol

jsr12711-math-0001.png


where Z denotes the objective function that we wish to minimize. The optimization variables ti and Di represent the time (in hours after the first wake‐up time in the schedule) and the caffeine amount (in mg) of dose i, respectively, with i = 1, 2, …, n (the number of doses). AUC denotes the area under the PVT mean response time (RT) curve above the baseline, and WP the difference between the peak of the mean RT curve and the baseline. C(ti, Di) denotes the level of caffeine in the blood. The subscripts C and NC denote caffeine and no caffeine, respectively. The last term penalizes the objective function when the maximum value of C(ti, Di) is higher than the maximum caffeine level achieved by a single dose of 400 mg, denoted by Cmax.


i was gonna try to make up some kind of bullshit explanation that was going to end, "now you've drunk so much coffee, you sit up all night watching cinemax"......but i haven't drunk enough coffee yet
 
Back
Top