It also depends on how your growing. I grow outside on my own property. I have a small organic garden with raised beds setup out back. Over here I get horn worms, grass hoppers, slugs, and snails. Plus in the summer the day time heat gets as high as 110*F. In my experience, healthy plants get less pests and are able to weather the heat better. So when I'm growing, I like to get the healthiest strains that I can afford.
F1s tend to the be most healthiest by default, but it also depends on how the parents were grown and what region or temperatures they were acclimated to. Next in line is F5+, what are stable strains and are basically the equivalent to a landrace strain.
F2 are healthy, but have a wide pheno variation. Bad if your looking for a large consistent harvest, but good if your looking to find the hardiest strains and get them acclimated to your region through selective breeding. F3s are the same as F2s, but slightly less variation, because some phenos would have been breed out through human or natural selection.
Having said this, if you know your friend is a good grower. You've seen with your own eyes just how healthy his plants are. And he's nice enough to gift you a few beans, then why not grow them? Even if they're F2's, it just means you'll need to grow a few more to find that prized strain. However, the none prized strains will still be good. Just as good as most mids that you buy at a dispensary.