im attempting to do that as we speak... its working out great for me so far, but you'd probably want to run both a humidifier as well as a dehumidifier so condensation doesnt build up too much.. I have one of the vents close to the floor cracked open a little with a fan blowing in at an angle from the outside to avoid direct air hitting anything and i leave the zipper open a little on the front to help with pulling air through. although, i am a rookie so id wait for more than just my response if i were you lol.