Yer better off meditating, this might help decalcify the pineal gland
CBD regulates Ca 2⫹ homeostasis and mediates neuroprotection in neuronal preparations. Imaging studies in hippocampal cultures using fura-2 AM sug-
gested that CBD-mediated Ca 2⫹ regulation is bidirectional, depending on the excitability of cells. Under physiological K ⫹ /Ca 2⫹ levels,
CBD caused a subtle rise in [Ca 2⫹ ] i , whereas CBD reduced [Ca 2⫹ ] i and prevented Ca 2⫹ oscillations under high-excitability conditions
(high K ⫹ or exposure to the K ⫹ channel antagonist 4AP). Regulation of [Ca 2⫹ ] i was not primarily mediated by interactions with
ryanodine or IP 3 receptors of the endoplasmic reticulum. Instead, dual-calcium imaging experiments with a cytosolic (fura-2 AM) and a
mitochondrial (Rhod-FF, AM) fluorophore implied that mitochondria act as sinks and sources for CBD’s [Ca 2⫹ ] i regulation. Application
of carbonylcyanide-p-trifluoromethoxyphenylhydrazone (FCCP) and the mitochondrial Na ⫹ /Ca 2⫹ exchange inhibitor, CGP 37157, but
not the mitochondrial permeability transition pore inhibitor cyclosporin A, prevented subsequent CBD-induced Ca 2⫹ responses. In
established human neuroblastoma cell lines (SH-SY5Y) treated with mitochondrial toxins, CBD (0.1 and 1 M ) was neuroprotective
against the uncoupler FCCP (53% protection), and modestly protective against hydrogen peroxide- (16%) and oligomycin- (15%) medi-
ated cell death, a pattern also confirmed in cultured hippocampal neurons. Thus, under pathological conditions involving mitochondrial
dysfunction and Ca 2⫹ dysregulation, CBD may prove beneficial in preventing apoptotic signaling via a restoration of Ca 2⫹ homeostasis.
but tripping's easier
I swam around the universe with the cosmic consioussness when i was small child, before that we played in the comfy zone before anything came to be, we created everything you don't know about and things that you do know.
shroom's, acid, d.m.t are toy's for the mind to play with,
Children never grow up, they just get bigger & more expensive toy's
Soooo is that any help