I've smoked since 1964. About 5 or 6 times in that many years I have been knocked on my ass so hard it was unreal. Severe vertigo, the sensation of flying at warp speed into space feet first and a few other freaky feelings. Every time it was from Mexican sativa sensimilla, not laced with anything. One time it was Panama Red. These are rated like 8 and 8.5 by Leafly while I have smoked others rated higher and driven around on it. IMHO sativa highs are the ones that will send most people flying. Those used to shorter grow period indicas, especially hydroponic product, who have limited exposure to a sativa that has been allowed to mature naturally - spelled S-L-O-W - in soil might be kicked hard.