My wife LOVES Mass Effect. I think it's pretty cool that the third installment is implementing voice commands via the Connect. I might even try it out myself.
Generally I only stick to fps games. Been playing the BF3 multiplayer beta. Started out playing strong, but then started getting my butt whooped. LoL. I think I'm sold on it, though.
I'm not completely sold on MW3, but I'll probably still get it. I love the MW series.
Gears of War was okay, but still ended up trading it in.
Dead Space. Very cool! I've stopped half way through the second one, though. Don't know if I'll pick it up again.
Now the Quake series was fucking awesome!