No, not at all. It's pretty widely accepted that blue light won't produce buds quite as dense as red light, but, on the other hand, it's said that blue light stimulates more trich(resin) production, which could make for a slightly more potent smoke. I've never tested either of those myself, or looked into it with any real depth, but I can say that your buds will turn out great. Yes, there will be a slight difference, but nothing major. Throw in a handful of red CFLs, and fill in the spectrum, if you want the best of both worlds.