I ignored changing my res's the first year and all my harvests were kinda small and my buds were not very big. After that, I changed the resevoirs every 2 weeks, except at the end of weeks 6, 7, and 8. I changed these intervals after 1 week as the Fox Farm feeding formula calls for nute changes at the end of each of those weeks. Also, week 6 is not only a resevoir change, but also a flush with a clearing solution in the water, so you literally change the water TWICE that day. I add GH celaring solution to my water and let the system run for 2 hrs then drain again and refill with the Week 7 feeding levels.
The flush clears excess salts and nutrient build up from your roots.....making for vigorous feeding in the flowering stage also.
To clarify, by weeks 6, 7, & 8, I am not referring to flowering weeks. I am referring to overall plant cycle, making these change times actually the 2nd, 3rd, & 4th weeks of flowering.
And remember, pH test your water daily. If your pH gets horribly out of control, drain your resevoir and and start with the correct pH.