This is an extremely complex topic, that begins with how cannabis is bred in general. I'm going to try not to go to longwith this, but basically, if botanists hot to start fresh with cannabis, they would start there bedding projects with only hardened land race strains, (somewhere between 30-50 generations deep minimum), and bag seed genetics, even epic winners like Chemdog, would not be bred with Until a hardened inbred line was established. Things like feminized seeds, are in a very dumbed down way akin to poorly inbreeding a pure bred dog line, or why many of the oldest, wealthiest, most inbred families suffer from genetic hemophilia. They simply are not stable enough for a legitimate breeding project and the scientific community already have there handful trying to categorize the genetic cesspool of cannabis. Fem. Bred seeds are far more likely to suffer from polypody, and transgenerational non genetic deformation. There's just no good reason to do so, but if your just popping seeds for yourself for meds, go for it.