My grow room is built in an unheated pole barn. It is not technichally a sealed room, but every seam is caulked inside and out...So, unless I create air flow via my exhaust running and pulling fresh air in via my 6" intake, there is close to zero air exchange.
I was worried about the tradeoff between pumping freezing air in and having enough CO2. After tapping the smart guys (and gals) around here, I went with no exhausting at all during veg, or at lights out during flower. When lights were on during flower, I ran the exhaust 4 times for 15 minutes over the 12 hours.
So the only CO2 my plants got was when I opened the door during veg and when I opened the door or during the limited exhausting during flower and guess what??? My plants stayed green and my goal of increasing yields every grow was met.
Bottom line, I concluded that adding CO2 to an unsealed room would be a waste of time and unecessary as the need is actually small and fufilled pretty much by opening the door.