Yes. I just did this, put a 5 ton split in a basement this past winter. I live in Michigan. I opened up a hole in an old chimney and put 8" elbow in it, and got two reducers, 8-10" & 10-12". And used a 12" fan 1700 cfm. Has worked fine so far. But springs almost here so I got my fingers crossed. I suggest building a small room around unit and passive intake from outside. Just depends on your location and setup. But make the room small. Your going to want to exchange the air in there serveral times a min imo.
So if your room is 6x6x8 you'll exchange the air every 10 seconds. Trust me it's not overkill. They put off alot of heat. Chimneys the best cover to dispose of hot air. Also basement is best location imo. Coolest place. And if you live there you could always heat your house with that air all winter. Again, setup and location will matter in your case.
Where you located?