Note that the other variable that has only be alluded to is whether you've got something that's showing sativa traits rather than indica traits. Things that lean sativa or heavily sativa are just going to stretch more.
Being a glutton for failure, I'm about to do a few runs that are sativa. The plan is to do something close to a mainline to keep it low and switch to flower ASAP once it's situated. It may be an abject failure, but whatev. I'm also only going to do 2 plants instead of 4, which is what I've run before, so I can make sure they've got enough space to spread horizontally as well as having room for verticality.
I'll probably lean into the lights a bit more than normal while they're seedlings too...keep the node spacing compact.